The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats
The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats
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DOI：
10.1016/s0024-3205(01)01552-1
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发表时间：
2002-03-15
期刊：
影响因子：
6.1
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Murata, P;Kase, Y;Nakamura, T
The present study investigated the effects of the herbal medicine Dai-kenchu-to (DKCT) and its 4 individual ingredients on intestinal blood flow (IBF) in rats by laser Doppler flowmetry. Intraduodenal administration of DKCT (30, 100 and 300 mg/kg) increased IBF in a dose-dependent manner, whereas the mean arterial blood pressure was not affected. One of the ingredients in DKCT is dried ginger rhizome (150 mg/kg), whose main component is [6]-shogaol (2 mg/kg), both of which showed similar in effects to those shown by DKCT, while the other ingredients in DKCT only slightly creased IBF or had no effect. The calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP (8-37), completely abolished the hyperemia induced by DKCT, dried ginger rhizome and [6]-shogaol. However, the vasoactive intestinal polypeptide (VIP) receptor antagonist, [4-0-DPhe6, Leu17]-VIP, and atropine were less inhibitory than CGRP (8-37), and the substance P (SP) receptor antagonist, spantide, had no effect. The present study demonstrated that DKCT and one of its active components, [6]-shogaol, produced an increase in IBF which was mainly mediated by CGRP and suggests that DKCT may be useful in the treatment of intestinal ischemia-related diseases. (C) 2002 Elsevier Science Inc. All rights reserved.
