Duration of nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae: Experiences from the south Swedish pneumococcal intervention project
Duration of nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae: Experiences from the south Swedish pneumococcal intervention project
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DOI：
10.1086/516103
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发表时间：
1997-11-01
影响因子：
11.8
通讯作者：
Persson, K
中科院分区：
文献类型：
--
作者：
Ekdahl, K;Ahlinder, I;Persson, K
作为干预项目的一部分，通过每周一次的鼻咽培养，对瑞典南部Malmohus县所有检测到的青霉素耐药肺炎球菌（PRP）（MIC，大于或等于0.5 mg/L）携带者进行随访。678人的携带时间中位数为19天（范围，3-267天）。18岁儿童的携带时间最长（中位数为14天）。在急性感染期间进行培养的指示病例是携带者，平均比无症状接触病例长10天（P <0.05）。PRP在4周内从鼻咽自发消失的个体占68%，在8周内87%，在12周内94%。长期携带的其他重要危险因素是急性中耳炎（AOM）发作>6次或在1岁之前首次发作AOM（P <0.01），其他家庭成员携带PRP（P <0.05），以及在冬季获得首次阳性培养（P <0.05）。
As a part of an intervention project, all detected carriers of penicillin-resistant pneumococci (PRP) (MIC, greater than or equal to 0.5 mg/L) in Malmohus County, southern Sweden, were followed by means of weekly nasopharyngeal cultures. The median duration of carriage in 678 individuals was 19 days (range, 3-267 days). The duration of carriage was longest in children 18 years old (median, 14 days). Index cases, whose cultures were performed during an acute infection, were carriers for a mean of 10 days longer than asymptomatic contact cases (P < .05), The PRP spontaneously disappeared from the nasopharynx within 4 weeks in 68%, within 8 weeks in 87%, and within 12 weeks in 94% of the individuals. Other significant risk factors for prolonged carriage were the occurrence of >6 episodes of acute otitis media (AOM) or first episode of AOM before the age of 1 year (P < .01), the carriage of PRP by other family members (P < .05), and the obtainment of a first positive culture during the winter months (P < .05).