In vivo activity of the LHRH pulse generator as determined with push-pull perfusion of the anterior pituitary gland of unrestrained intact and castrate male rats.
In vivo activity of the LHRH pulse generator as determined with push-pull perfusion of the anterior pituitary gland of unrestrained intact and castrate male rats.
复制标题
通过对未受限制的完整和去势雄性大鼠的垂体前叶进行推拉灌注来确定 LHRH 脉冲发生器的体内活性。
作者：
D. Dluzen;V. Ramirez
在这篇文章中，我们报告了在活体中，去势后在垂体前叶测得的LHRH产量显著增加，这是由于更大和更频繁的LHRH信号到达该腺体。这与在下丘脑内使用推拉式插管的去势雄鼠的幅度和总体平均LHRH释放减少形成对比。这些不同的结果产生了一篇关于性腺类固醇在LHRH脉冲发生器中的作用的新论文。本文认为，去势后，下丘脑内侧基底核的LHRH信号频率增加，幅度降低，但整个下丘脑LHRH释放的同步性增加，导致LHRH到达垂体前叶的频率和幅度增加。
In the present article we report that in vivo LHRH output as measured at the anterior pituitary following castration significantly increased, due to larger and more frequent LHRH signals arriving to this gland. This contrasts with the decreased amplitude and overall mean LHRH release of castrate males bearing a push-pull cannula within the hypothalamus. These divergent results have generated a new thesis regarding the role of gonadal steroids upon the LHRH pulse generator. This thesis submits that following castration there is an increased frequency and decreased amplitude of the LHRH signal from discrete loci within the medial basal hypothalamus, but an increased synchrony of LHRH release throughout the entire hypothalamus, resulting in an increased frequency and amplitude of LHRH arriving at the anterior pituitary.