Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics.
Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics.
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DOI：
10.3390/ph7090913
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发表时间：
2014-09-04
期刊：
影响因子：
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通讯作者：
Pierzchalska M
中科院分区：
文献类型：
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作者：
Grabacka MM;Gawin M;Pierzchalska M
线粒体不仅对维持能量稳态至关重要，而且在一般意义上对维持适当的细胞功能至关重要。在多种病理状态中观察到线粒体功能受损，例如肿瘤转化和癌症、神经退行性疾病、代谢紊乱和慢性炎症。目前，在经典的药物设计方法的同时，人们对筛选天然生物活性物质（主要是植物化学物质）的兴趣越来越大，以便为上述病理学开发新的治疗方案。膳食植物化学物质，如白藜芦醇，姜黄素和萝卜硫素是非常好的耐受性，可以有效地补充经典的药理学治疗方案。在本文中，我们讨论了所选择的植物化学物质（例如，白藜芦醇、姜黄素、萝卜硫素）对线粒体生物学的各个方面的作用，即线粒体生物发生、膜电位和活性氧物质产生、向细胞核和从细胞核发出信号以及未折叠蛋白质反应。
Mitochondria are crucially important for maintaining not only the energy homeostasis, but the proper cellular functions in a general sense. Impairment of mitochondrial functions is observed in a broad variety of pathological states such as neoplastic transformations and cancer, neurodegenerative diseases, metabolic disorders and chronic inflammation. Currently, in parallel to the classical drug design approaches, there is an increasing interest in the screening for natural bioactive substances, mainly phytochemicals, in order to develop new therapeutic solutions for the mentioned pathologies. Dietary phytochemicals such as resveratrol, curcumin and sulforaphane are very well tolerated and can effectively complement classical pharmacological therapeutic regimens. In this paper we disscuss the effect of the chosen phytochemicals (e.g., resveratrol, curcumin, sulforaphane) on various aspects of mitochondrial biology, namely mitochondrial biogenesis, membrane potential and reactive oxygen species production, signaling to and from the nucleus and unfolded protein response.