Combination of Foot Stimulation and Tramadol Treatment Reverses Irritation Induced Bladder Overactivity in Cats
Combination of Foot Stimulation and Tramadol Treatment Reverses Irritation Induced Bladder Overactivity in Cats
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DOI：
10.1016/j.juro.2012.07.110
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发表时间：
2012-12-01
影响因子：
6.6
通讯作者：
Tai, Changfeng
中科院分区：
文献类型：
--
作者：
Mally, Abhijith D.;Zhang, Fan;Tai, Changfeng
Purpose: We determined whether transcutaneous electrical foot stimulation combined with a low dose of tramadol (Sigma-Aldrich (R)) could completely suppress bladder overactivity.Materials and Methods: Repeat cystometrograms were performed in 18 alpha-chloralose anesthetized cats by infusing the bladder with saline or 0.25% acetic acid. Transcutaneous electrical stimulation (5 Hz) of the cat hind foot at 2 to 4 times the threshold intensity needed to induce observable toe movement was applied to suppress acetic acid induced bladder overactivity. Tramadol (1 to 3 mg/kg intravenously) was administered to enhance foot inhibition.Results: Acetic acid irritated the bladder, induced bladder overactivity and significantly decreased bladder capacity to a mean +/- SE of 26% +/- 5% of saline control capacity (p
