Effect of Metamucil on tumour formation by 1,2-dimethylhydrazine dihydrochloride in mice.
Effect of Metamucil on tumour formation by 1,2-dimethylhydrazine dihydrochloride in mice.
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Metamucil 对 1,2-二甲基肼二盐酸盐在小鼠体内形成肿瘤的影响。
DOI：
10.1016/0278-6915(84)90228-x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Toth,B
中科院分区：
文献类型：
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作者：
Toth,B
用随机饲养的瑞士小鼠研究了植物纤维素metamucil对1，2-二甲基肼二盐酸盐（1，2-DMH）致瘤性的影响。对实验开始时为5、6和6周龄的三组小鼠给予以下治疗：（1）在其寿命期内，在粉末饮食中的metamucil（20%，w/w）;（2）1，2-DMH，以20 mg/kg体重每周皮下注射十次;（3）对组1和2给予治疗的组合。metamucil的管理增强了外观的结肠肿瘤诱导的1，2-DMH在男性中。Metamucil对1，2-DMH在另外7个部位引起的肿瘤发展没有统计学显著影响。据估计，大量的膳食纤维将抑制大肠中的致癌作用。相反，metamucil增加了由1，2-DMH诱导的结肠肿瘤的发病率，尽管仅在男性中。
The effect of the plant cellulose metamucil on the tumorigenicity of 1,2-dimethylhydrazine dihydrochloride (1,2-DMH) was studied in random-bred Swiss mice. Three groups of mice, which were 5, 6 and 6 weeks old at the beginning of the experiment, were given the following treatments: (1) metamucil (20%, w/w) in powdered diet for their lifespan; (2) 1,2-DMH, ten weekly subcutaneous injections at 20 mg/kg body weight; (3) combination of treatments given to groups 1 and 2. The administration of metamucil enhanced the appearance of colon tumours induced by 1,2-DMH in males only. Metamucil had no statistically significant effect on the development of tumours elicited by 1,2-DMH at seven additional sites. It was expected that a high amount of dietary fibre would inhibit carcinogenesis in the large intestine. Instead, metamucil increased the incidence of colon tumours induced by 1,2-DMH, although only in males.