Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia.
Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia.
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脑脊液 HVA、中枢脑萎缩和精神分裂症的临床状态。
DOI：
10.1016/0165-1781(86)90099-5
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发表时间：
1986
影响因子：
11.3
通讯作者：
Javors,MA
中科院分区：
文献类型：
--
作者：
Houston,JP;Maas,JW;Bowden,CL;Contreras,SA;McIntyre,KL;Javors,MA
在16例慢性精神分裂症患者中，脑脊液（CSF）中高香草酸（HVA）浓度与脑第三脑室大小的计算机断层扫描测量值呈显著负相关。停药期间的临床状态也与CSF HVA水平显著相关，但当CSF HVA的影响部分消失时，与第三脑室大小无关。作者认为这些发现可能反映了第三脑室周围结构的萎缩过程和多巴胺能活性的降低。
In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.