Hyperpolarizing Water with Parahydrogen
Hyperpolarizing Water with Parahydrogen
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DOI：
10.1002/cphc.201700750
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发表时间：
2017-09-20
期刊：
影响因子：
2.9
通讯作者：
Schleker, P. Philipp M.
中科院分区：
文献类型：
--
作者：
Lehmkuhl, Soeren;Emondts, Meike;Schleker, P. Philipp M.
水基系统的研究是核磁共振（NMR）和磁共振成像（MRI）的基础兴趣，因为水是全球生命最丰富和最重要的介质。因此，增加水和溶解化合物的极化对生物医学应用特别有吸引力，例如分子间相互作用和代谢物结构的研究以及成像目的。在这项工作中，我们展示了一种基于对富氢（p-H-2）的新方法，如果采用合适的催化系统，则可以实现散装水的超极化。结果表明，极化是通过一种新的交换机制转移的。
Studies of water-based systems are of fundamental interest for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) as water is the most abundant and important medium for global living. Hence, increasing the polarization of water and dissolved compounds is particularly attractive for biomedical applications such as investigations of intermolecular interactions and metabolite structures as well as for imaging purposes. In this work, we show a new approach based on para enriched hydrogen (p-H-2) that enables the hyperpolarization of bulk water if a suitable catalytic system is employed. The results indicate that the polarization is transferred by a new exchange mechanism.