Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice
Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice
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DOI：
10.1172/jci13288
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发表时间：
2001-12-01
影响因子：
15.9
通讯作者：
Krieger, M
中科院分区：
文献类型：
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作者：
Miettinen, HE;Rayburn, H;Krieger, M
哺乳动物雌性生育力取决于卵巢和卵巢外环境之间复杂的相互作用（例如，下丘脑-垂体卵巢轴）。使用HDL受体SR-BI敲除（KO）小鼠检查血浆脂蛋白在生育力中的作用。SR-BI KO雌性动物HDL异常，排卵功能障碍的卵母细胞，并且不育。当通过失活apoAI基因或给予降胆固醇药物普罗布考改变异常HDL的结构和/或数量时，生育能力恢复。这表明脂蛋白代谢异常可导致小鼠不育-意味着功能性肝-卵巢轴-并可能导致某些形式的人类女性不育。
Mammalian female fertility depends on complex interactions between the ovary and the extraovarian environment (e.g., the hypothalamic-hypophyseal ovarian axis). The role of plasma lipoproteins in fertility was examined using HDL-receptor SR-BI knockout (KO) mice. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes, and are infertile. Fertility was restored when the structure and/or quantity of abnormal HDL was altered by inactivating the apoAI gene or administering the cholesterol-lowering drug probucol. This suggests that abnormal lipoprotein metabolism can cause murine infertility - implying a functional hepatic-ovarian axis - and may contribute to some forms of human female infertility.