Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation
Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation
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DOI：
10.1016/j.pain.2005.10.030
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发表时间：
2006-01-01
期刊：
影响因子：
7.4
通讯作者：
Sluka, KA
中科院分区：
文献类型：
--
作者：
Ainsworth, L;Budelier, K;Sluka, KA
经皮神经电刺激（TENS）通过涉及脊髓和脑干部位的中枢机制减轻疼痛。由于TENS通过中枢机制起作用，我们假设当将TENS应用于同侧或对侧肌肉炎症部位时，TENS将减轻单侧炎症引起的慢性双侧痛觉过敏。在sd - dawley大鼠左腓肠肌腹部注射卡拉胶。分别在注射卡拉胶前和注射后2周进行双侧机械戒断阈值测试。在2周测试戒断阈值后，大鼠在炎症部位的同侧或对侧接受TENS治疗。在每一组中，大鼠随机分为对照组（无TENS）、低频（4 Hz）和高频（100 Hz） TENS治疗组。在轻度氟烷麻醉下，以感觉强度施加TENS 20 min。经TENS或不经TENS治疗后重新评估机械戒断阈值。单侧腓肠肌注射卡拉胶可显著降低2周后双侧机械脱脱阈值（机械性痛觉过敏）。低频或高频TENS应用于炎症部位同侧腓肠肌，可显著逆转炎症部位同侧和对侧的机械性痛觉过敏。在炎症部位对侧腓肠肌上应用低频或高频TENS也能显著减轻与炎症部位同侧和对侧的机械性痛觉过敏。由于在该动物模型中，同侧或对侧TENS治疗可有效减轻慢性双侧痛觉过敏，我们认为TENS通过调节来自脊柱上部位（如吻侧腹内侧髓质（RVM））的下行影响而起作用。(c) 2005年国际疼痛研究协会。Elsevier B.V.版权所有。
Transcutaneous electrical nerve stimulation (TENS) reduces pain through central mechanisms involving spinal cord and brainstem sites. Since TENS acts through central mechanisms, we hypothesized that TENS will reduce chronic bilateral hyperalgesia produced by unilateral inflammation when applied either ipsilateral or contralateral to the site of muscle inflammation. Sprague-Dawley rats were injected with carrageenan in the left gastrocnemius muscle belly. Mechanical withdrawal threshold was tested bilaterally before and 2 weeks after carrageenan injection. After testing withdrawal thresholds at 2 weeks, rats received TENS treatment either ipsilateral or contralateral to the site of inflammation. In each of these groups, rats were randomized to control (no TENS), low frequency (4 Hz), or high frequency (100 Hz) TENS treatment. TENS was applied for 20 min at sensory intensity under light halothane anesthesia. Mechanical withdrawal thresholds were re-assessed after TENS or 'no TENS' treatment. Unilateral injection of carrageenan to the gastrocnemius muscle significantly reduced the mechanical withdrawal threshold (mechanical hyperalgesia) bilaterally 2 weeks later. Either low or high frequency TENS applied to the gastrocnemius muscle ipsilateral to the site of inflammation significantly reversed mechanical hyperalgesia, both ipsilateral and contralateral to the site of inflammation. Low or high frequency TENS applied to the gastrocnemius muscle contralateral to the site of inflammation also significantly reduced mechanical hyperalgesia, both ipsilateral and contralateral to the site of inflammation. Since ipsilateral or contralateral TENS treatments were effective in reducing chronic bilateral hyperalgesia in this animal model, we suggest that TENS act through modulating descending influences from supraspinal sites such as rostral ventromedial medulla (RVM). (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.