A survey of EPA/OPP and open literature on selected pesticide chemicals - II. Mutagenicity and carcinogenicity of selected chloroacetanilides and related compounds
A survey of EPA/OPP and open literature on selected pesticide chemicals - II. Mutagenicity and carcinogenicity of selected chloroacetanilides and related compounds
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DOI：
10.1016/s1383-5742(99)00019-8
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发表时间：
1999-07-15
影响因子：
1.9
通讯作者：
Waters, MD
中科院分区：
文献类型：
--
作者：
Dearfield, KL;McCarroll, NE;Waters, MD
通过这一努力，我们继续审查已提交给美国环境保护署（USEPA）农药计划办公室（OPO）的选定农药化学品及其相关类似物的数据。本报告重点介绍了一组选定的氯乙酰苯胺和一些相关化合物。作为农药化学品注册程序的一部分，相关方（注册人）必须提交毒性信息以支持注册，包括致突变性和致癌性数据。虽然公众可以通过向科学和技术委员会提出的信息自由要求获得这些信息，但在科学文献中发表可以更好地传播和审查这些数据。在这份特刊中，我们绘制了提交给OPP的致突变性和致癌性数据的图表。此外，我们还讨论了如何使用毒性数据来帮助建立耐受性（食品中农药残留的限值）。注册人提交的致突变性结果由来自公开文献的这些化学品的数据补充，以提供其遗传毒理学的完整视角。本文综述的氯乙酰苯胺组显示一致的致突变活性模式，可能通过代谢物介导。在暴露于此类化学品的实验动物中观察到的肿瘤发展中，这种致突变活性是一个机械上合理的因素。(C)1999 Elsevier Science B.V.保留所有权利。
With this effort, we continue our examination of data on selected pesticide chemicals and their related analogues that have been presented to the U.S. Environmental Protection Agency's (USEPA's) Office of Pesticide Programs (OPP). This report focuses on a group of selected chloroacetanilides and a few related compounds. As part of the registration process for pesticidal chemicals, interested parties (registrants) must submit toxicity information to support the registration including both mutagenicity and carcinogenicity data. Although this information is available to the public via Freedom of Information (FOI) requests to the OPP, publication in the scientific literature allows greater dissemination and examination of the data. For this Special Issue, graphic profiles have been prepared of the mutagenicity and carcinogenicity data available in the submissions to OPP. Also, a discussion is presented about how toxicity data are used to help establish tolerances (limits of pesticide residues in foods). The mutagenicity results submitted by registrants are supplemented by data on these chemicals from the open literature to provide a full perspective of their genetic toxicology. The group of chloroacetanilides reviewed here display a consistent pattern of mutagenic activity, probably mediated via metabolites. This mutagenic activity is a mechanistically plausible factor in the development of tumors seen in experimental animals exposed to this class of chemicals. (C) 1999 Elsevier Science B.V. All rights reserved.