ANTI-SDA A NEW BLOOD GROUP ANTIBODY
ANTI-SDA A NEW BLOOD GROUP ANTIBODY
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DOI：
10.1111/j.1423-0410.1967.tb03796.x
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发表时间：
1967-01-01
期刊：
影响因子：
2.7
通讯作者：
GOLDSMITH, KL
中科院分区：
文献类型：
--
作者：
RENTON, PH;HOWELL, P;GOLDSMITH, KL
一种名为抗Sda的新血型抗体与大多数成年高加索人血液样本反应，在大量游离细胞中产生明确的凝集物。单个红细胞样本之间的反应强度差异很大，如果使用1级EDTA，则可获得最佳凝集效果。技术与含有强效抗γ M抗体的抗球蛋白试剂一起使用，或者如果在2阶段补体结合抗球蛋白技术中使用酶处理的细胞。Sd（a+）者的红细胞大多可能携带Sda抗原，抗原强度可能与个体红细胞的年龄无关。所有检查的脐带血红细胞样本均呈阴性反应。该抗体似乎是一种补体固定γ-M球蛋白，抗原在血清学上与其他主要血型系统无关。
A new blood-group antibody named anti-Sda reacts with most adult Caucasian blood samples giving a characteristic appearance of well-defined agglutinates among a large number of free cells. The strength of the reaction varies widely between individual red-cell samples the best agglutination being obtained if a 1-stage EDTA. technique is used with an antiglobulin reagent that contains a potent anti-gammaM antibody, or if enzyme-treated cells are used in a 2-stage complement binding antiglobuin technique. Most of the red cells of Sd(a+) persons may carry the Sda antigen, and the antigen strength may not be related to the age of individual red cells. All cord blood red-cell samples examined gave negative reactions. The antibody appears to be a complement fixing gammaM globulin and the antigen to be serologically independent of the other main blood group systems.