Assessment of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D3 concentrations in male and female multiple sclerosis patients and control volunteers
Assessment of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D3 concentrations in male and female multiple sclerosis patients and control volunteers
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DOI：
10.1177/1352458506072666
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发表时间：
2007-06-01
期刊：
影响因子：
--
通讯作者：
Wallace, J. M. W.
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文献类型：
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作者：
Barnes, M. S.;Bonham, M. P.;Wallace, J. M. W.
紫外线照射不足和饮食中维生素 D 含量低的人群的维生素 D 状态（血浆 25-羟基维生素 D (25(OH)D) 浓度）较低，据报道多发性硬化症 (MS) 的发病率较高。维生素 D 的活性形式 1,25-二羟基维生素 D-3 (1,25(OH)(2)D-3) 是一种有效的抗炎分子。迄今为止，尚无研究评估 MS 个体中 1,25(OH)2D3 的浓度。在这项研究中，测量了 29 名 MS 患者和 22 名年龄和性别匹配的对照志愿者的 25(OH)D、1,25(OH)(2)D-3 和甲状旁腺激素 (PTH) 的血浆浓度。 MS 患者和对照志愿者之间的血浆 PTH、25(OH)D 和 1,25(OH)2D3 浓度没有显着差异。女性多发性硬化症患者的 25(OH)D 和 1,25(OH)2D3 浓度显着高于男性多发性硬化症患者（分别为 79.1 +/- 45.4 与 50.2 +/- 15.3nmol/L，P=0.019 和 103.8 +/- 36.8 与 70.4 +/- 28.7pmol/L，P=0.019）。所有受试者的 25(OH)D 和 1,25(OH)(2)D-3 浓度之间均存在显着正相关 (r=0.564，P=0.000)，但二次分析显示这种相关性是由患有 MS 的女性驱动的 (r=0.677，P=0.001)。观察到维生素 D 代谢存在显着的性别差异，并且在 MS 个体中最为明显，这表明不同性别以及潜在疾病状态对维生素 D 的需求可能有所不同。
Populations with insufficient ultraviolet exposure and who consume diets low in vitamin D have low vitamin D status (plasma 25-hydroxyvitamin D (25(OH)D) concentrations) and a reported higher incidence of multiple sclerosis (MS). The active form of vitamin D, 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), is an effective anti-inflammatory molecule. No research to date has assessed 1,25(OH)2D3 concentrations in individuals with MS. In this study, plasma concentrations of 25(OH)D, 1,25(OH)(2)D-3 and parathyroid hormone (PTH) were measured in 29 individuals with MS and 22 age- and sex-matched control volunteers. There were no significant differences in plasma PTH, 25(OH)D and 1,25(OH)2D3 concentrations between individuals with MS and control volunteers. Women with MS had significantly higher 25(OH)D and 1,25(OH)2D3 concentrations than men with MS (79.1 +/- 45.4 versus 50.2 +/- 15.3nmol/L, P=0.019 and 103.8 +/- 36.8 versus 70.4 +/- 28.7pmol/L, P=0.019, respectively). There was a significant positive correlation between 25(OH)D and 1,25(OH)(2)D-3 concentrations in all subjects (r=0.564, P=0.000), but secondary analysis revealed that the correlation was driven by women with MS (r=0.677, P=0.001). Significant sex differences in vitamin D metabolism were observed and were most marked in individuals with MS ' suggesting that vitamin D requirements may differ between the sexes, as well as by underlying disease state.