Ultrastructural And Quantitative Motoneuronal Changes After Ventral Root Avulsion Favor Early Surgical Repair
Ultrastructural And Quantitative Motoneuronal Changes After Ventral Root Avulsion Favor Early Surgical Repair
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DOI：
10.1076/1381345520000710831zft293
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发表时间：
2000-01
影响因子：
3
通讯作者：
C. Holtzer;H. Feirabend;E. Marani;R. Thomeer
中科院分区：
文献类型：
--
作者：
C. Holtzer;H. Feirabend;E. Marani;R. Thomeer
本研究评估了前根撕脱伤后运动神经元发生的定性和定量形态学变化。本实验观察了存活2、8、14、30、60和90天猫颈7脊髓前角运动神经元核周的变化。一般来说，大的运动神经元表现出一个轻的类型的反应，和小的或轻或暗。此外，还发现了具有正常超微结构外观的神经元，后者被认为处于“稳定状态”，这可能与再生能力有关。所有这些类型的神经元反应都存在于所有的存活时间，但由特定反应标记的细胞数量取决于存活时间。定性和定量的证据给出了撕脱后2至14天之间的运动神经元群体中的36%的细胞死亡。这种减少主要涉及大的，大概是运动神经元与光型反应。很小吧？14天后运动神经元受到严重影响。这些发现表明，早期手术修复可能有更好的临床恢复的机会。
This study assesses qualitative and quantitative morphological changes that occur in motoneurons after ventral root avulsion. The motoneuronal perikaryal changes in the ventral horn of the cat’s C7 cord segment were studied after survival times of 2, 8, 14, 30, 60 and 90 days. Generally, large motoneurons showed a light type of reaction, and the small ones either light or dark. In addition, neurons with a normal ultrastructural appearance were found. These latter are considered to be in a ‘steady state’, which may be associated with regenerative potency. All these types of neuron reactions were present at all survival times, but the number of cells marked by a specific reaction depends on the time of survival. Qualitative and quantitative evidence is given for cell death in 36% of the motoneuronal population between 2 and 14 days after avulsion. This reduction primarily concerns large, presumably a motoneurons with the light type reaction. Small, presumably ? motoneurons become seriously affected after 14 days. These findings suggest that early surgical repair may have the better chances for clinical recovery.