Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method
Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method
复制标题
DOI：
10.1109/nssmic.2007.4437112
复制
发表时间：
2007-10
期刊：
影响因子：
--
通讯作者：
M. Naganawa;H. Tsukada;H. Ohba;K. Ishiwata;C. Seki;M. Shidahara;Y. Kimura
中科院分区：
文献类型：
--
作者：
M. Naganawa;H. Tsukada;H. Ohba;K. Ishiwata;C. Seki;M. Shidahara;Y. Kimura
在动态正电子发射断层扫描(PET)研究中，在生理参数的定量估计中，需要连续采集动脉血来测量血液输入函数。然而，由于允许的血液量有限，血液采样对于动物PET研究是有问题的。因此，避免动脉采血是有意义的。我们以前在人体研究中提出了一种基于独立成分分析的血液输入曲线估计方法。在本文中，我们将该方法应用于猴子[18F]氟脱氧葡萄糖的研究，并通过比较使用估计的和测量的血液输入函数估计的大脑局部葡萄糖代谢率来验证该方法的适用性。实验结果表明，该方法不仅在人体数据中，而且在猴子数据中，不需要连续采集动脉血就可以对PET进行定量分析。
Serial arterial blood sampling is required to measure a blood input function in quantitative estimation of physiological parameters in dynamic positron emission tomography (PET) studies. However, blood sampling is problematic for animal PET study due to limited amount of blood allowed. Therefore, it is of interest to obviate arterial blood sampling. We have previously proposed a method for estimating a blood input curve based on independent component analysis in human study. In this paper, we applied the method to monkey [18F]fluorodeoxyglucose studies, and validated its applicability by comparing the estimated regional cerebral metabolic rates of glucose using the estimated and the measured blood input function. Experimental results suggest that the proposed method enables quantitative analysis in PET without serial arterial blood sampling not only in human data but also in monkey data.