Angiotensin-II-induced hypertension chemotherapy: evaluation of hepatic blood flow with oxygen-15 PET.
Angiotensin-II-induced hypertension chemotherapy: evaluation of hepatic blood flow with oxygen-15 PET.
复制标题
血管紧张素 II 诱导的高血压化疗：用氧 15 PET 评估肝血流量。
DOI：
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发表时间：
1996
影响因子：
9.3
通讯作者：
Toshio Takahashi
中科院分区：
文献类型：
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作者：
Hiroki Taniguchi;H. Koyama;Mamoru Masuyama;Atsushi Takada;Tatsuroh Mugitani;Hiroki Tanaka;M. Hoshima;Toshio Takahashi
我们使用15 O-二氧化碳（稳态）和15 O-水（动态）PET成像定量测量了两名患者肝实质和肝肿瘤的血流量。在血管紧张素II给药前和给药期间采集图像，以达到高血压状态。肝细胞癌血流大于肝实质血流。结肠转移灶内血流与实质相似，中心低于周围。在血管紧张素II诱导的高血压状态下，原发性和继发性肝肿瘤的血流量没有变化，而肝实质的血流量减少。结果，在PET图像上，高血压状态下肿瘤血流量相对增加。此外，在高血压状态下，脾脏血流量下降至基线的55%。这些发现表明，高血压癌症化疗可以保护正常组织。此外，PET显像可能能够预测肝癌患者高血压化疗的疗效。
We quantitatively measured blood flow in liver parenchyma and hepatic tumors in two patients using 15O-carbon dioxide (steady state) and 15O-water (dynamic) PET imaging. Images were acquired before and during administration of angiotensin-II to achieve a hypertensive state. Blood flow in the hepatocellular carcinoma was greater than that of the parenchyma. Blood flow in the colon metastasis was similar to that in the parenchyma and lower in the center than in the periphery. During a hypertensive state induced by angiotensin II, blood flow in both the primary and secondary liver tumors did not change, while blood flow in the liver parenchyma decreased. As a result, there was a relative increase in tumor blood flow during the hypertensive state on PET images. Furthermore, blood flow to the spleen decreased to 55% of baseline during the hypertensive state. These findings suggest that hypertensive cancer chemotherapy may protect normal tissue. Furthermore, PET imaging may be able to predict the efficacy of hypertensive cancer chemotherapy in the patients with liver tumors.