Development of the inner ear
Development of the inner ear
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DOI：
10.1016/j.gde.2015.02.006
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发表时间：
2015-06-01
影响因子：
4
通讯作者：
Whitfield, Tanya T.
中科院分区：
文献类型：
--
作者：
Whitfield, Tanya T.
脊椎动物的内耳是一种设计精巧、灵敏度高的感觉器官。它对声音、重力和运动做出反应，同时具有听觉（听力）和前庭（平衡）功能。内耳的几乎所有细胞类型，包括感觉毛细胞、感觉神经元、分泌细胞和支持细胞，都来源于耳基板，耳基板是早期胚胎中前神经板边缘周围出现的几种外胚层增厚之一。从耳基板形成内耳的发育模式机制是多样而复杂的，包括重复使用熟悉的信号通路，以及转录因子、跨膜蛋白和细胞外基质成分的作用。在这篇评论中，我选择了一些亮点，说明了与这个迷人的器官系统的发展有关的许多最新发现中的一些。
The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, derive from the otic placode, one of the several ectodermal thickenings that arise around the edge of the anterior neural plate in the early embryo. The developmental patterning mechanisms that underlie formation of the inner ear from the otic placode are varied and complex, involving the reiterative use of familiar signalling pathways, together with roles for transcription factors, transmembrane proteins, and extracellular matrix components. In this review, I have selected highlights that illustrate just a few of the many recent discoveries relating to the development of this fascinating organ system.