Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries
Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries
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DOI：
10.1093/ajcn/68.2.425s
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发表时间：
1998-08-01
影响因子：
7.1
通讯作者：
Brown, KH
中科院分区：
文献类型：
--
作者：
Brown, KH
由于缺乏敏感、具体、低成本的锌状况指标，控制锌缺乏症的干预方案的制定受到阻碍。一组个体的平均血浆锌浓度被认为是一个人群锌状况的可能指标，因为血浆锌浓度似乎可以预测锌补充后是否会增加生长。然而，动物模型和成人志愿者的实验研究以及感染和未感染成人的临床研究表明，产生急性期反应的全身性感染也会导致血浆锌浓度下降。因此，人们对血浆锌浓度作为高感染率人群锌状态指标的有效性提出了关注。与上述对成人的研究相反，对有和没有常见感染的儿童进行的横断面、基于社区的调查没有发现感染与血浆锌浓度之间的任何关联，这可能是因为在野外环境中观察到的儿童感染的严重程度低于所研究的成人感染。因此，平均血浆锌浓度可能是低收入国家儿童锌状况的有用指标，尽管在这些环境中常见的儿童感染发病率很高。
The development of intervention programs to control zinc deficiency is hampered by the lack of sensitive, specific, low-cost indicators of zinc status. The mean plasma zinc concentration of groups of individuals has been suggested as a possible indicator of a population's zinc status because the plasma zinc concentration seems to predict whether growth will increase in response to zinc supplementation. However, experimental studies in both animal models and adult human volunteers as well as clinical studies of infected and noninfected adults indicate that systemic infections that produce an acute phase response also cause the plasma zinc concentration to fall. Therefore, concerns have been raised about the usefulness of plasma zinc concentration as an indicator of zinc status in populations with high prevalences of infections. By contrast with the aforementioned studies in adults, cross-sectional, community-based surveys of children with and without common infections have not found any association between the presence of infection and plasma zinc concentration, possibly because the severity of those infections observed in children in field settings was less than that of the infections studied in adults. Thus, it appears that the mean plasma zinc concentration may be a useful indicator of population zinc status for children in low-income countries despite the high prevalence of common childhood infections encountered in these settings.