Gene expression pattern Cloning and expression of a novel zinc ® nger gene , Fez , transcribed in the forebrain of Xenopus and mouse embryos
Gene expression pattern Cloning and expression of a novel zinc ® nger gene , Fez , transcribed in the forebrain of Xenopus and mouse embryos
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发表时间：
2000
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通讯作者：
M. Matsuo‐Takasaki;Jae-hwan Lim;M. Beanan;Sheryl M. Sato;T. Sargent
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作者：
M. Matsuo‐Takasaki;Jae-hwan Lim;M. Beanan;Sheryl M. Sato;T. Sargent
我们已经识别并克隆了一种新型的zinc ®nger基因Fez（前脑胚胎zinc ®nger），作为爪蟾前神经板形成的潜在下游决定因素。艾德。Fez是作为由神经化因子noggin诱导的几种神经特异性基因之一分离的（Smith和Harland，1992.细胞70，829±840），在未定型外胚层。Fez具有包含466个氨基酸的开放阅读框，并且含有六个C2 H2型zinc ®nger结构域，其在果蝇、zebra®sh、小鼠和人类中高度保守。在非洲爪蟾中，Fez的表达开始于阶段12的神经板的吻端，到阶段45，它定位于几个端脑区域，包括嗅球、终神经和脑室区。Fez的小鼠同源物在胚胎第11天的小鼠前脑中也有类似的表达。q 2000爱思唯尔科学爱尔兰有限公司保留所有权利。
We have identi®ed and cloned a novel zinc ®nger gene, Fez (forebrain embryonic zinc-®nger), as a potential downstream determinant of anterior neural plate formation in Xenopus. Fez was isolated as one of several neural-speci®c genes that was induced by the neuralizing factor, noggin (Smith and Harland, 1992. Cell 70, 829±840), in uncommitted ectoderm. Fez has an open reading frame comprising 466 amino acids, and contains six C2H2 type zinc ®nger domains, which are highly conserved among Drosophila, zebra®sh, mouse, and human. In Xenopus, the expression of Fez begins at stage 12 in the rostral end of the neural plate, and by stage 45, it is localized to several telencephalic regions, including the olfactory bulbs, nervus terminalis, and ventricular zone. The mouse homologue of Fez is similarly expressed in the mouse forebrain by embryonic day 11. q 2000 Elsevier Science Ireland Ltd. All rights reserved.