Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans
Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans
复制标题
DOI：
10.1159/000069464
复制
发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Fumagalli, L
中科院分区：
文献类型：
--
作者：
Lissoni, P;Rovelli, F;Fumagalli, L
研究表明，细胞因子活动受神经内分泌控制，近期主要由松果体通过其主要激素褪黑激素（MLT）的昼夜分泌来发挥作用。它主要在夜间释放，但目前还不清楚MLT与细胞因子的昼夜分泌是否存在关系。本研究旨在评估IL-2、IL-6、IL-10和IL-12的昼夜分泌与MLT的关系。这项研究包括10名健康志愿者，他们的静脉血样本分别在上午8点、中午、下午4点、晚上8点、凌晨1点和凌晨4点采集。MLT的平均水平在夜间明显高于白天的光照期。同样，IL-2平均水平在夜间显著升高。白天亮时IL-6平均值较高，但与夜间平均值无显著差异。最后，IL-10和IL-12的平均浓度没有明显的昼夜变化。这些结果表明，IL-2分泌在夜间增加，伴随松果体激素MLT的分泌，而没有证据表明其他细胞因子的昼夜分泌。由于松果体已被证明可以刺激IL-2内源性产生，因此夜间IL-2血药浓度的增加可能至少部分取决于MLT的促进作用，MLT的释放在白天的黑暗时期增加。
It has been demonstrated that cytokine activities are under neuroendocrine control, recently mainly exerted by the pineal gland through the circadian secretion of its main hormone melatonin (MLT). It is mainly released during the night, but at present it is still unclear which relation exists between MLT and the circadian secretion of cytokines. This study was performed to evaluate the circadian secretion of IL-2, IL-6, IL-10 and IL-12 in relation to that of MLT. The study included 10 healthy volunteers whose venous blood samples were collected at 8 a.m., noon, 4 p.m., 8 p.m., I a.m. and 4 a.m. The mean levels of MLT were significantly higher during the night than during the light phase of the day. Similarly, IL-2 mean levels significantly increased during the night. IL-6 mean values were higher during the light period of the day without, however, any significant differences with respect to the nocturnal mean levels. Finally, no substantial circadian variation was seen in IL-10 and IL-12 mean concentrations. These results show that IL-2 secretion increases during the night, concomitantly to that of the pineal hormone MLT, whereas there is no evidence of a circadian secretion for the other cytokines. Since the pineal gland has been proven to stimulate IL-2 endogenous production, the nocturnal increase in IL-2 blood concentrations could depend at least in part on the promoting action of MLT, whose release increases during the dark period of the day.