Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope
Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope
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DOI：
10.1016/j.amjhyper.2006.05.010
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发表时间：
2006-12-01
影响因子：
3.2
通讯作者：
Nawata, Hajime
中科院分区：
文献类型：
--
作者：
Yanase, Toshihiko;Nasu, Shigeru;Nawata, Hajime
颈动脉内膜-中层厚度(IMT)是动脉粥样硬化和冠心病(CHD)的一个指标，通常在颈动脉B超下通过目测来评估。然而，该系统的轴向分辨率为：>；=0.1 mm，这就给精度和重复性带来了困难。我们评估了由创新测量软件Intimascope(Media Cross Co.Ltd.，日本东京)编程的新开发的B超颈动脉超声，该软件测量IMT的轴向分辨率提高了10倍，估计尺寸为0.01 mm。计算机平均IMT(AVER-IMT)值和3点IMT值的观察者内或观察者间变异系数(CV)明显小于传统目测法的相应值(3点值)。我们测量了427名接受体检的无症状受试者(243名男性和184名女性，年龄在23到73岁)的IMT。427例受试者的平均IMT和3点IMT与人眼测量法相近，但平均IMT的标准差和变异系数最小。在男性和女性中，多元回归分析显示年龄和低密度脂蛋白胆固醇对平均IMT值有显著贡献。单因素回归分析显示，所有受试者的平均IMT值与大多数危险因素和风险评估评分、Framingham风险评估或前瞻性心血管明斯特研究(Procam)风险评分呈高度相关。这些结果可能表明，无论是通过基于计算机的测量方法还是通过眼部测量方法，基于计算机的AVER-IMT都优于基于计算机的三点IMT。使用新的Intimascope软件测量颈动脉Aver-IMT可能比传统的IMT测量提供更准确和更可重复性的动脉粥样硬化指数。
Carotid intima-media thickness (IMT), an indicator of atherosclerosis and coronary heart disease (CHD) is usually evaluated by eye measurement under B-scope carotid artery ultrasonography. However, the axial resolution of this system is : >= 0.1 mm, which causes difficulties in respect to accuracy and reproducibility. We evaluated a newly developed B-scope carotid artery ultrasonography programmed by an innovative measurement software, Intimascope (Media Cross Co. Ltd., Tokyo, Japan), which measures IMT with 10 times higher axial resolution at an estimated scale of 0.01 mm. Intraobserver or interobserver coefficient of variation (CV) of the computer-based average IMT (aver-IMT) value and 3-point IMT value were much smaller than the corresponding value by conventional eye-measurement method (3-point value). We measured IMT of 427 asymptomatic subjects undergoing medical checkups (243 men and 184 women, 23 to 73 years of age). Although the mean values of aver-IMT and 3-point IMT of 427 subjects were comparable with that of the eye measurement method, the aver-IMT showed the smallest SD (standard deviation) and CV values. In both men and women, multivariate regression analysis revealed significant contributions of age and LDL-C to the aver-IMT value. Univariate regression analysis revealed that the aver-IMT value of total subjects showed the hi.-hest correlation coefficient values with most risk factors and risk assessment score, Framingham Risk Assessment, or Prospective Cardiovascular Munster study (PROCAM) Risk Score. These results may suggest superiority of computer-based aver-IMT over 3-point IMT by either computer-based or eye measurement method. Carotid aver-IMT measurement using the new Intimascope software may provide a more precise and reproducible index of atherosclerosis than does conventional IMT measurement.