All normal rat hepatocytes produce albumin at a rate related to their degree of ploidy.
All normal rat hepatocytes produce albumin at a rate related to their degree of ploidy.
复制标题
所有正常大鼠肝细胞产生白蛋白的速度与其倍性程度相关。
DOI：
10.1016/0006-291x(81)91853-2
复制
发表时间：
1981
影响因子：
3.1
通讯作者：
A. Guillouzo
中科院分区：
文献类型：
--
作者：
E. Le Rumeur;C. Beaumont;C. Guillouzo;M. Rissel;M. Bourel;A. Guillouzo
白蛋白的本地化和其分泌率确定在原始悬浮液中，并在2n和4n亚群获得的逆流离心，正常成年大鼠肝细胞。在淘析之前和之后，在内质网和高尔基体的水平上，在所有或几乎所有的肝细胞中发现白蛋白。由4n肝细胞组分分泌的白蛋白的量大约是由2n肝细胞组分分泌的2倍。这些结果表明，在任何单个时间点，所有成年大鼠肝细胞产生白蛋白的速率与其倍性程度直接相关。
Albumin was localized and its rate of secretion determined in the original suspension and in the 2n and 4n subpopulations obtained by counter-flow centrifugation, of normal adult rat hepatocytes. Albumin was found in all or almost all the hepatocytes both before and after elutriation, at the level of the endoplasmic reticulum and the Golgi apparatus. The amount of albumin secreted by the 4n hepatocyte fractions was roughly 2-fold that secreted by the 2n hepatocyte fractions. These results suggest that at any single time point, all adult rat hepatocytes produce albumin at a rate directly correlated with their degree of ploidy.