Emerging diverse roles of telocytes
Emerging diverse roles of telocytes
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DOI：
10.1242/dev.175018
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发表时间：
2019-07-01
期刊：
影响因子：
4.6
通讯作者：
Kaestner, Klaus H.
中科院分区：
文献类型：
--
作者：
Kondo, Ayano;Kaestner, Klaus H.
自1911年首次描述哺乳动物肠道中的“Cajal间质细胞”以来，科学家们在全身许多组织中发现了结构相似的细胞，现在称为端细胞。这些细胞最近引发了新的兴趣，通过分子手柄的发展来促进基因操纵它们在组织稳态和疾病中的功能。在这篇文章中，我们讨论了端细胞的发现，它们的物理特性，分布和功能，重点是Foxl1阳性端细胞在肠道干细胞生态位中的功能分析的最新进展，最后，研究端细胞作为一种独特的细胞类型的当前挑战。
Since the first description of 'interstitial cells of Cajal' in the mammalian gut in 1911, scientists have found structurally similar cells, now termed telocytes, in numerous tissues throughout the body. These cells have recently sparked renewed interest, facilitated through the development of a molecular handle to genetically manipulate their function in tissue homeostasis and disease. In this Primer, we discuss the discovery of telocytes, their physical properties, distribution and function, focusing on recent developments in the functional analysis of Foxl1-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of studying telocytes as a distinct cell type.