Noise propagation in gene networks
Noise propagation in gene networks
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DOI：
10.1126/science.1109090
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发表时间：
2005-03-25
期刊：
影响因子：
56.9
通讯作者：
van Oudenaarden, A
中科院分区：
文献类型：
--
作者：
Pedraza, JM;van Oudenaarden, A
准确预测基因网络中的噪声传播对于理解自然网络中的信号保真度和设计抗噪声基因电路至关重要。为了量化噪声如何通过基因网络传播，我们测量了单细胞中基因之间的表达相关性。我们发现，基因中的噪声是由其内在的波动，从上游基因传递的噪声，以及影响所有基因的全局噪声决定的。开发了一个模型，解释了相关性所表现出的复杂行为，并揭示了占主导地位的噪声源。该模型成功地预测了网络系统扰动时的相关性。这种方法为理解和操纵更复杂的基因网络中的噪声传播提供了一个步骤。
Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity in natural networks and designing noise-tolerant gene circuits. To quantify how noise propagates through gene networks, we measured expression correlations between genes in single cells. We found that noise in a gene was determined by its intrinsic fluctuations, transmitted noise from upstream genes, and global noise affecting all genes. A model was developed that explains the complex behavior exhibited by the correlations and reveals the dominant noise sources. The model successfully predicts the correlations as the network is systematically perturbed. This approach provides a step toward understanding and manipulating noise propagation in more complex gene networks.