Cellular Reprogramming as a Therapeutic Target in Cancer
Cellular Reprogramming as a Therapeutic Target in Cancer
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细胞重编程作为癌症的治疗靶点
DOI：
10.1016/j.tcb.2019.05.001
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发表时间：
2019
影响因子：
19
通讯作者：
Lin Cheng
中科院分区：
文献类型：
--
作者：
Shumin Xiong;Ye Feng;Lin Cheng
长期以来，癌症异质性一直被认为是患者预后的重要临床决定因素，因此，许多新的癌症治疗方法都是针对这些不同的细胞设计的。尽管目前的治疗方法，包括化疗、抗血管生成疗法、放疗和免疫疗法在短期内取得了成就，但癌症消退的长期成功仍然很差。因此，研究人员研究了癌症中的一个新特性——细胞重编程，它不仅有助于癌症的经典特征，而且表明癌症是一个动态事件，而不是一个静态的细胞实体。在这里，我们讨论了癌细胞的细胞重编程可以解释癌细胞中观察到的一些表型和功能异质性的机制。
Cancer heterogeneity has long been recognized as an important clinical determinant of patient outcomes and, thus, many new cancer treatments have been designed to target these different cells. Despite the short-term achievements of current therapies, including chemotherapy, antiangiogenesis therapy, radiotherapy, and immunotherapy, the long-term success of cancer regression remains poor. Therefore, researchers have investigated a new property, cellular reprogramming, in cancer that not only contributes to the classic hallmarks of cancer, but also suggests that cancer is a dynamic event rather than a static cellular entity. Here, we discuss the mechanisms by which the cellular reprogramming of cancer cells can explain some of the phenotypic and functional heterogeneity observed among cancer cells.