Thyrotropin secretion in genetically obese rats.
Thyrotropin secretion in genetically obese rats.
复制标题
遗传性肥胖大鼠的促甲状腺素分泌。
DOI：
10.1210/endo-90-1-67
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发表时间：
1972
期刊：
影响因子：
4.8
通讯作者：
G. Bray
中科院分区：
文献类型：
--
作者：
D. York;J. Hershman;R. Utiger;G. Bray
下丘脑-垂体-甲状腺轴已在遗传性肥胖大鼠、瘦同窝小鼠和下丘脑损伤（病变）后变得肥胖的同窝小鼠中进行了研究。暴露于寒冷（3℃）后，遗传性肥胖大鼠的甲状腺放射性半衰期从4.73 d降低至2.44 d；血浆FFA未见升高，体温明显下降。瘦的同窝仔鼠的甲状腺半衰期从 1.73 天减少到 0.92 天，FFA 出现预期的上升，但体温没有下降。病变大鼠甲状腺碘释放量无变化，但FFA增加，体温无明显变化。在维持在 18°C 的大鼠中，遗传性肥胖大鼠的垂体重量显着减少，但瘦大鼠和遗传性肥胖大鼠的促甲状腺素 (TSH) 浓度相似。饲喂补充有丙硫氧嘧啶的饮食后，脂肪中的血浆 TSH 略有上升。当遗传性肥胖大鼠进食时，血浆 TSH 没有升高...
The hypothalamic-pituitary-thyroid axis has been studied in genetically obese rats, in lean littermates and littermates which became obese following hypothalamic injury (lesioned). After exposure to cold (3°C), the half-life for thyroid radioactivity in the genetically obese rats decreased from 4.73 d to 2.44 d; the plasma FFA showed no elevation and body temperature fell significantly. Lean littermates had a decrease in thyroidal half-life from 1.73 d to 0.92 d, showed the expected rise in FFA but had no fall in body temperature. Lesioned rats had no change in release of thyroid iodine but increased their FFA, and showed no significant change in body temperature. In rats maintained at 18°C the weight of the pituitary was significantly reduced in the genetic obese rats, but the concentration of thyrotropin (TSH) was similar in lean and genetically obese rats. Plasma TSH in fatties rose slightly after feeding a diet supplemented with propylthiouracil. Plasma TSH did not rise when genetic obese rats were fe...