Epinephrine administration at birth prevents long-term changes in dopaminergic parameters caused by Cesarean section birth in the rat
Epinephrine administration at birth prevents long-term changes in dopaminergic parameters caused by Cesarean section birth in the rat
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DOI：
10.1007/s00213-008-1213-9
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发表时间：
2008-10-01
影响因子：
3.4
通讯作者：
Zhang, Ying
中科院分区：
文献类型：
--
作者：
Boksa, Patricia;Zhang, Ying
分娩缺氧引起的产科并发症与多巴胺能功能障碍（如精神分裂症）的病因有关。剖宫产（c -剖宫产）在人类和大鼠中都与轻度呼吸窘迫增加和出生时循环儿茶酚胺水平降低有关，儿茶酚胺通常是为肺部提供准备和激活其他促进子宫外适应的过程。利用大鼠模型，研究人员发现，与阴道分娩相比，剖腹产分娩可以产生中枢神经系统（CNS）多巴胺功能的长期变化。目的观察出生时给药外源性肾上腺素能否逆转大鼠剖宫产后多巴胺能参数的长期变化。结果在成年期无应激的情况下，剖宫产大鼠和顺产大鼠体内酪氨酸羟化酶（TH）活性和多巴胺转运体（DAT）结合水平无差异。然而，在成年期反复轻度应激后，与阴道出生的对照组相比，剖腹产大鼠伏隔核的TH活性增加，背纹状体和伏隔核的DAT增加。对刚出生的剖腹产大鼠单次注射肾上腺素，可以阻止成年后反复轻度应激后剖腹产大鼠TH活性和DAT结合的增加。出生时的肾上腺素也有部分逆转安非他明诱导的成年后剖腹产大鼠运动增加的趋势。这些结果表明，新生儿出生时循环儿茶酚胺水平的变化可能有助于中枢神经系统功能的微妙长期变化。
Rationale Obstetric complications involving birth hypoxia are implicated in the etiology of disorders with dopaminergic dysfunction, such as schizophrenia. Cesarean section (C-section) birth in both humans and rats is associated with increased mild respiratory distress and with reduced levels of circulating catecholamines at birth, which normally serve to prime the lungs and activate other processes promoting extrauterine adaptation. Using a rat model, it has been found that C-section birth can produce long-term changes in central nervous system (CNS) dopamine function, compared to vaginal birth.Objective The present experiments tested if administering exogenous epinephrine at birth could reverse long-term changes in dopaminergic parameters in C-sectioned rats.Results In the absence of stress at adulthood, no differences were observed between C-sectioned and vaginally born rats in levels of in vivo tyrosine hydroxylase (TH) activity and dopamine transporter (DAT) binding. However, after repeated mild stress at adulthood, C-sectioned rats showed increased TH activity in nucleus accumbens and increased DAT in dorsal striatum and accumbens, compared to vaginally born controls. A single injection of epinephrine to C-sectioned rats just after birth prevented the increased TH activity and DAT binding seen in C-sectioned rats after repeated mild stress at adulthood. There was also a trend for epinephrine at birth to partially reverse an increase in amphetamine-induced locomotion seen in C-sectioned rats at adulthood.Conclusions These results suggest that variations in levels of circulating catecholamines in the neonate at the time of birth could contribute to subtle long-term changes in CNS function.