Transdermal delivery of methotrexate:: iontophoretic delivery from hydrogels and passive delivery from microemulsions
Transdermal delivery of methotrexate:: iontophoretic delivery from hydrogels and passive delivery from microemulsions
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DOI：
10.1016/s0378-5173(00)00674-8
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发表时间：
2001-03-14
影响因子：
5.8
通讯作者：
Blanco-Méndez, J
中科院分区：
文献类型：
--
作者：
Alvarez-Figueroa, MJ;Blanco-Méndez, J
体外实验研究了两种类型的水凝胶和两种类型的微乳液的离子电渗给药的甲氨蝶呤（MTX）的经皮给药的有效性。MTX从水凝胶和被动递送从微乳液的离子电渗递送比被动递送从药物的水溶液更有效。在离子电渗递送测定中，所使用的水凝胶的类型和负载溶液中的药物浓度对递送的有效性几乎没有影响。在被动递送测定中，我们使用水/油（w/o）和油/水（o/w）微乳液：o/w系统的递送有效性更高。在所有试验结束时，在皮肤中检测到显著量的MTX。这些结果表明，水凝胶和微乳液可能是有价值的局部给药MTX治疗银屑病。(C)2001爱思唯尔科技有限公司。保留所有权利。
In vitro assays were performed to investigate the effectiveness of transdermal administration of methotrexate (MTX) by iontophoretic delivery from two types of hydrogel and passive delivery from two types of microemulsion. Both iontophoretic delivery of MTX from hydrogels and passive delivery from microemulsions were more effective than passive delivery from aqueous solutions of the drug. In the iontophoretic delivery assays, the type of hydrogel used and the concentration of the drug in the loading solution had little influence on effectiveness of delivery. In the passive delivery assays, we used both water/oil (w/o) and oil/water (o/w) microemulsions: effectiveness of delivery was higher from o/w systems. At the end of all assays, significant amounts of MTX were detected in the skin. These results suggest that both hydrogels and microemulsions may be of value for the topical administration of MTX in the treatment of psoriasis. (C) 2001 Elsevier Science B.V. All rights reserved.