Peroxisome proliferator-activated receptor (PPAR) γ polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women.
Peroxisome proliferator-activated receptor (PPAR) γ polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women.
复制标题
绝经后妇女的过氧化物酶体增殖物激活受体 (PPAR) γ 多态性、维生素 D、骨矿物质密度和牙周炎。
作者：
Wang Y;Sugita N;Yoshihara A;Iwasaki M;Miyazaki H;Nakamura K;Yoshie H
目的PPARg调节骨代谢和炎症反应。我们以前的研究表明PPARg Pro 12 Ala多态性是日本孕妇牙周炎的易感因素。最近的几篇论文引起了人们对绝经后妇女低骨密度（BMD）和牙周炎之间可能联系的关注。由于两者的发病机制都涉及骨重建，因此它们可能具有共同的风险因素，如基因多态性和维生素D水平。本研究探讨了PPARgPro 12 Ala多态性，牙周炎，骨密度和血清25（OH）D绝经后的日本women.Materials和MethodsPPARgPro 12 Ala基因型的359名妇女之间的可能关联进行了测定，通过PCR-RFLP。测量每位妇女的BMD和牙周参数。结果PPARgPro 12 Ala基因多态性与牙周炎及骨密度无明显相关性。Ala等位基因携带者的血清25（OH）D显著高于非携带者。仅在Ala等位基因携带者中，平均临床附着水平与BMD、BMD与25（OH）D、探诊深度≥4 mm的位点百分比与25（OH）D呈正相关。然而，多态性可能是一个调制器的绝经后日本妇女的两个条件之间的关系。
ObjectivesPPARg regulates bone metabolism and inflammation. Our previous study suggested PPARg Pro12Ala polymorphism to represent a susceptibility factor for periodontitis in pregnant Japanese women. Several recent papers have drawn attention to a possible link between low bone mineral density (BMD) and periodontitis in postmenopausal women. Since the pathogenesis for both involve bone remodeling, they might share common risk factors such as gene polymorphisms and vitamin D level. The present study investigated possible associations between the PPARgPro12Ala polymorphism, periodontitis, BMD and serum 25(OH)D in postmenopausal Japanese women.Materials and MethodsPPARgPro12Ala genotypes of 359 women were determined by PCR‐RFLP. BMD and periodontal parameters of each woman were measured. Serum 25(OH)D levels were determined by radioimmunoassay.ResultsPPARgPro12Ala polymorphism was not associated with periodontitis or BMD as an independent factor. Serum 25(OH)D was significantly higher in Ala allele carriers compared to non‐carriers. Only in the Ala allele carriers, positive correlations were found between mean clinical attachment level and BMD, between BMD and 25(OH)D, and between percentage of sites with probing depth ≥4 mm and 25(OH)D.ConclusionsPPARgPro12Ala polymorphism was not independently associated with periodontitis or BMD. However, the polymorphism might be a modulator of the relationship between the two conditions in postmenopausal Japanese women.