Structure of a γδ T cell receptor in complex with the nonclassical MHC T22
Structure of a γδ T cell receptor in complex with the nonclassical MHC T22
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DOI：
10.1126/science.1106885
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发表时间：
2005-04-08
期刊：
影响因子：
56.9
通讯作者：
Garcia, KC
中科院分区：
文献类型：
--
作者：
Adams, EJ;Chien, YH;Garcia, KC
γ δ T细胞受体（TCR）、α β TCR和抗体是体细胞重组抗原受体的三个谱系。配体识别的结构基础良好。定义为α β TCR和抗体，但缺乏γ δ TCR。我们目前的3.4埃结构的小鼠γ δ TCR G8结合其主要组织相容性复合体（MHC）的Ib类配体，T22。G8主要使用其8链互补决定区3（CDR 3）环的种系-en编码残基以与α β TCR/肽-MHC中所见的方向基本上不同的方向结合T22。连接蛋白编码的G8残基在结合中起辅助作用，表明先天和适应性识别策略的融合。
gamma delta T cell receptors (TCRs), alpha beta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well. defined for alpha beta TCR and antibodies but is lacking for gamma delta TCRs. We present the 3.4 angstrom structure of the murine gamma delta TCR G8 bound to its major histocompatibillity complex (MHC) class Ib ligand, T22. G8 predominantly uses germ line-en coded residues of its 8 chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alpha beta TCR/peptide-MHC. That junctionaily encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.