Recoverable hearing loss with amphetamines and other drugs
Recoverable hearing loss with amphetamines and other drugs
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DOI：
10.1080/02791072.2004.10399740
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发表时间：
2004-06-01
影响因子：
2.8
通讯作者：
Iqbal, N
中科院分区：
文献类型：
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作者：
Iqbal, N
据报告，长期和持续地饮酒、吸食海洛因和挥发物会损害听力。安非他明相关的听力损失在临床上与其他药物引起的听力损失不同。似乎非法药物的使用可能导致两种临床上不同类型的听力损失。2001年5月和6月，183名年龄在18岁及以上、符合DSM-IV物质依赖标准的男性在沙特阿拉伯桑迪亚的一家医院接受了研究。这项研究的目的是确定安非他明相关的可恢复性听力损失的流行率，确定滥用其他药物是否也发生类似的听力损失，并确定与药物有关的精神病是否在出现这类听力损失的安非他明使用者中更为普遍。可恢复型听力损失不仅见于安非他明使用者，也见于大麻、海洛因、酒精、美沙芬和胶水使用者。在那些出现听力损失的安非他明使用者中，药物引起的精神病是其他人的3.5倍。重度抑郁症和自杀倾向在这些人中也更常见。重度抑郁症和随后听力损失的发展之间的这种联系也在使用其他类型药物的人中发现。得出的结论是，历史上的严重抑郁症是一个很好的预测后期发展的药物引起的精神病和听力损失的安非他明用户，和低灌注提出了可能的解释。
Prolonged and sustained consumption of alcohol, heroin and volatiles had been reported to impair hearing. Amphetamine related hearing loss is clinically different from the hearing loss seen with other agents. It seems that illicit drug use could result in two clinically different types of hearing losses. In May and June of 2001, 183 men aged 18 and above who met DSM-IV criteria for substance dependence were studied in a hospital in Sandia Arabia. The purpose of the study was to ascertain the prevalence of amphetamine-related recoverable hearing loss, establish whether similar hearing loss also occurred with other drugs of abuse and determine if drug-related psychosis was more prevalent in those amphetamine users who developed this type of hearing loss. Recoverable type of hearing loss was not just seen in amphetamine users but also occurred with cannabis, heroin, alcohol, dextromethorphan and glue use. Drug-induced psychosis was three and a half times more common in those amphetamine users who developed a hearing loss. Major depression and suicidality was also more common in these individuals. This association of major depression and subsequent development of hearing loss was also found in those using other type of drugs. It was concluded that a history of major depression was a good predictor of later development of both drug-induced psychosis and hearing loss in amphetamine users, and hypoperfusion was proposed as the possible explanation.