Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion.
Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion.
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DOI：
10.2147/opth.s37185
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Nishida K
中科院分区：
文献类型：
--
作者：
Sakimoto S;Kamei M;Suzuki M;Yano S;Matsumura N;Sakaguchi H;Gomi F;Nishida K
探讨视网膜分支静脉阻塞（BRVO）黄斑周围视网膜血流灌注与黄斑中心凹厚度的关系。入组了74例连续BRVO患者的74只眼。我们开发了一种新的分级系统，以评估黄斑周围视网膜灌注状态，分为三个等级：完全灌注区（FPA），部分灌注区（PPA）和非灌注区（NPA），使用荧光素血管造影。评估这些等级与光学相干断层扫描测量的中央凹厚度（CFT）之间的相关性。我们还通过比较以中心凹为中心的1-、2-和3-椎间盘直径（DD）水平半圆区域的相关系数，确定了灌注状态与中心凹厚度之间相关性最密切的区域。确定每个灌注等级的程度与CFT之间的相关性。三个地区的CFT与FPA呈显著负相关（r = 0.31，P = 0.006），与PPA呈显著正相关（r = 0.45，P < 0.001）。最显着的相关性被发现在2-DD区。有趣的是，NPA与任何区域的中央凹厚度都不相关。部分但不完全毛细血管损失的区域似乎是与BRVO相关的黄斑水肿的原因。应研究针对PPA中扩张毛细血管渗漏的治疗。
To study the relationship between retinal perfusion around the macula and the foveal thickness in branch retinal vein occlusion (BRVO). Seventy-four eyes of 74 consecutive patients with BRVO were enrolled. We developed a new grading system to evaluate the status of retinal perfusion around the macula in three grades: full perfusion area (FPA), partial perfusion area (PPA), and nonperfusion area (NPA), using fluorescein angiography. The correlation was assessed between these grades and the central foveal thickness (CFT) measured by optical coherence tomography. We also determined the area with the closest correlation between the perfusion status and the foveal thickness by comparing the correlation coefficient in areas of 1-, 2-, and 3-disc diameter (DD) horizontal hemicircles centered at the fovea. The correlation was determined between the extent of each perfusion grade and CFT. We found a significant negative correlation between the CFT and the FPA (r = 0.31, P = 0.006) and a significant positive correlation between the CFT and the PPA (r = 0.45, P < 0.001) in the three areas. The most significant correlations were found in the 2-DD area. Interestingly, the NPA has not correlated with the foveal thickness in any areas. The areas of partial but not complete capillary loss seem to be responsible for the macular edema associated with BRVO. Treatments targeting leakage from the dilated capillaries in the PPA should be investigated.