Sudden unexpected death in epilepsy. A nationwide population-based study
Sudden unexpected death in epilepsy. A nationwide population-based study
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DOI：
10.1111/epi.16349
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发表时间：
2019-09-30
期刊：
影响因子：
5.6
通讯作者：
Olafsson, Elias
中科院分区：
文献类型：
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作者：
Einarsdottir, Anna B.;Sveinsson, Olafur;Olafsson, Elias
目的不同研究中癫痫猝死（SUDEP）的发生率不同。我们确定了整个冰岛人口在20年期间的SUDEP发病率。方法纳入1991年1月1日至2010年12月31日期间冰岛所有意外死亡的癫痫患者。病例的确定是基于尸检、抗癫痫药物报销、死亡证明、神经科医生的信息和医疗记录。根据冰岛在研究期间的居民总数和冰岛估计的癫痫人群计算出SUDEP的发病率。结果37例（男性26例，女性11例）确诊SUDEP (n = 29)，确诊SUDEP合并（n = 4），疑似SUDEP （n = 4）。在一般人群中，SUDEP的发病率为每10万人年0.6例，男性发病率更高。癫痫人群中SUDEP的估计发病率为每1000人年1.3例。在研究期间，猝死症占冰岛所有死亡人数的0.1%。猝死症是劳动年龄人群死亡的重要原因。本研究提供了整个国家未选择人群中猝死症的发病率。癫痫人群的猝死事件发生率与既往研究相当。
Objective The incidence of sudden unexpected death in epilepsy (SUDEP) varies between studies. We determined the incidence of SUDEP in the entire Icelandic population during a 20-year period. Methods All individuals in Iceland with epilepsy who died unexpectedly from January 1, 1991 through December 31, 2010 were included. Case ascertainment was based on autopsies, reimbursement for antiepileptic drugs, death certificates, information from neurologists, and medical records. The incidence of SUDEP was calculated according to the total number of residents in Iceland during the study period and an estimated epilepsy population of Iceland. Results We identified 37 individuals (26 men, 11 women) with definite SUDEP (n = 29), definite SUDEP plus (n = 4), and probable SUDEP (n = 4). Incidence of SUDEP was 0.6 per 100 000 person-years for the general population, and higher among men. The estimated incidence of SUDEP in the epilepsy population was 1.3 per 1000 person-years. SUDEP accounted for 0.1% of all deaths in Iceland during the study period. Significance SUDEP is an important cause of death in working-age people. This study provides the incidence of SUDEP in an unselected population of an entire country. The SUDEP incidence in the epilepsy population is comparable to that of previous studies.