Six-Minute Walk Distance in Persons With Parkinson Disease: A Hierarchical Regression Model
Six-Minute Walk Distance in Persons With Parkinson Disease: A Hierarchical Regression Model
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DOI：
10.1016/j.apmr.2008.12.018
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发表时间：
2009-06-01
影响因子：
4.3
通讯作者：
Earhart, Gammon M.
中科院分区：
文献类型：
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作者：
Falvo, Michael J.;Earhart, Gammon M.
目的：确定帕金森病（PD）患者的6分钟步行距离（6 MWD），并确定影响步行能力的障碍。设计：PD患者的描述性横断面研究。设置：大学实验室。参与者：PD患者（N=75; 65.0 +/-9.5岁），根据平均Hoehn和Yahr（HY）评分2.0 +/- 0.4和统一帕金森病评分定义，干预措施：不适用。主要结果测量：受试者被给予运动亚部分的运动量表，并完成以下测试：贝格平衡量表（BBS），定时起身和行走（TUG），和六分钟步行测试。此外，他们还提供了自我报告的冻结步态和福尔斯的数量在过去6个月。结果：平均6 MWD为391.6 +/-99.9米。除跌倒次数（P= 0.07）外，所有上述测试均与6 MWD显著相关（r范围为-0.64至0.55）。通过使用分层回归模型，我们将年龄、HY和ADRS运动评分输入第一个模块（即一组自变量）以代表帕金森病特征，这解释了6 MWD的显著变异性（R-2= 0.196，P
Objectives: To determine the six-minute walk distance (6MWD) in subjects with Parkinson disease (PD) and to determine the impairments that contribute to walking capacity.Design: Descriptive cross-sectional study of subjects with PD.Setting: University laboratory.Participants: Subjects with PD (N=75; 65.0 +/- 9.5y) of mild to moderate Severity, as defined by an average Hoehn and Yahr (HY) rating of 2.0 +/- 0.4 and Unified Parkinson Disease Rating, Scale (UPDRS) motor score of 27 +/- 8.9, were tested on medication.Interventions: Not applicable.Main Outcome Measures: Subjects were administered the motor Subsection of the UPDRS and completed the following tests: Berg Balance Scale (BBS), Timed Up & Go (TUG), and six-minute walk test. In addition, they also provided self-reports of freezing of gait and number of falls in the past 6 months.Results: The average 6MWD was 391.6 +/- 99.9m. All of the aforementioned tests, with the exception of fall number (P=.07), correlated significantly with 6MWD (r range, -.64 to .55). By using a hierarchical regression model, we entered age, HY, and UPDRS motor score into the first block (ie, set of independent variables) to represent parkinsonian characteristics, which explained a significant amount of variability in 6MWD (R-2=.196, P