Prognostic Role of Glasgow Prognostic Score in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Prognostic Role of Glasgow Prognostic Score in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
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DOI：
10.1097/md.0000000000002133
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发表时间：
2015-12
期刊：
影响因子：
1.6
通讯作者：
Cai JQ
中科院分区：
文献类型：
--
作者：
Li MX;Bi XY;Li ZY;Huang Z;Han Y;Zhou JG;Zhao JJ;Zhang YF;Zhao H;Cai JQ
关于格拉斯哥预后评分（GPS）在肝细胞癌（HCC）患者中的预后价值的矛盾结果已被报道。我们检索了现有的文献，并进行了荟萃分析，以阐明GPS对HCC患者预后的预测价值。使用PubMed （Medline）、Embase、Cochrane Library、Web of Science、ChinaInfo和Chinese National Knowledge Infrastructure对截至2015年9月的所有年份进行了系统的文献检索。研究分析了GPS与生存结局的关系。计算风险比（HR）和95%置信区间（CI）来评估风险。最终共有10项研究纳入meta分析。合并估计结果显示，HCC患者GPS升高与总生存率较低之间存在显著关系（HR = 2.156, 95% CI: 1.696-2.740, P < 0.001）。GPS增高的患者有缩短无进展生存期的趋势（HR = 1.755, 95% CI: 0.943-3.265, P = 0.076）。GPS升高与Child-Pugh分级进展显著相关（优势比= 25.979,95% CI: 6.159 ~ 109.573, P < 0.001）。发表偏倚分析显示meta分析存在发表偏倚。格拉斯哥预后评分可能是HCC患者的独立预后因素。有必要进行更多设计良好、随访时间充足的研究。
Conflicting results about the prognostic value of Glasgow Prognostic Score (GPS) in hepatocellular carcinoma (HCC) patients have been reported. We searched the available articles and performed the meta-analysis to clarify the predictive value of GPS in HCC patients’ outcome. A systematic literature search was conducted using PubMed (Medline), Embase, Cochrane Library, Web of Science, ChinaInfo, and Chinese National Knowledge Infrastructure for all years up to September 2015. Studies analyzing the relationship of GPS and survival outcome were identified. Hazard ratio (HR) with 95% confidence interval (CI) was calculated to assess the risk. A total of 10 studies were finally enrolled in the meta-analysis. The pooled estimates demonstrated a significant relationship between elevated GPS and inferior overall survival in patients with HCC (HR = 2.156, 95% CI: 1.696–2.740, P < 0.001). Patients with increased GPS had a tendency toward shorter progression-free survival (HR = 1.755, 95% CI: 0.943–3.265, P = 0.076). And elevated GPS was found to be significantly associated with advanced Child–Pugh class (odds ratio = 25.979, 95% CI: 6.159–109.573, P < 0.001). The publication bias analysis revealed that there was publication bias in the meta-analysis. Glasgow Prognostic Score may be an independent prognostic factor in patients with HCC. More well-designed studies with adequate follow-up duration are warranted.