DEFECTIVE REPAIR REPLICATION OF DNA IN XERODERMA PIGMENTOSUM
DEFECTIVE REPAIR REPLICATION OF DNA IN XERODERMA PIGMENTOSUM
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DOI：
10.1038/218652a0
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发表时间：
1968-01-01
期刊：
影响因子：
64.8
通讯作者：
CLEAVER, JE
中科院分区：
文献类型：
--
作者：
CLEAVER, JE
正常皮肤成纤维细胞可以通过以小补丁的形式将新碱基插入DNA来修复UV辐射对DNA的损伤。来自患有遗传性疾病着色性干皮病的患者的细胞携带突变，使得与正常成纤维细胞相比，DNA的修复复制不存在或大大减少。着色性干皮病患者在暴露于阳光下时会发生致命的皮肤癌，因此皮肤中DNA修复的失败一定与致癌作用有关。
Normal skin fibroblasts can repair UV radiation damage to DNA by inserting new bases into DNA in the form of small patches. Cells from patients with the hereditary disease xeroderma pigmentosum carry a mutation such that repair replication of DNA is either absent or much reduced in comparison to normal fibroblasts. Patients with xeroderma pigmentosum develop fatal skin cancers when exposed to sunlight, and so the failure of DNA repair in the skin must be related to carcinogenesis.