LOCALIZATION OF GOLD IN MOUSE BRAIN IN RELATION TO GOLD THIOGLUCOSE OBESITY
LOCALIZATION OF GOLD IN MOUSE BRAIN IN RELATION TO GOLD THIOGLUCOSE OBESITY
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DOI：
10.1152/ajplegacy.1962.202.4.743
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发表时间：
1962-01-01
影响因子：
--
通讯作者：
SCHWARTZ, IL
中科院分区：
文献类型：
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作者：
DEBONS, AF;JOHNSON, HA;SCHWARTZ, IL
金硫代葡萄糖的管理导致小鼠的食欲过盛和肥胖的发展;这证实了以前的研究人员的发现。通过中子活化分析和放射自显影，观察到该综合征与下丘脑中的金的局灶性积聚有关。用硫代苹果酸金处理的动物未能显示任何放射自显影的金的下丘脑定位或任何摄食过多和肥胖综合征的证据。此外，在硫代葡萄糖金处理的动物中发现了其他金定位灶，但在硫代苹果酸金处理的动物中未发现。伽马能谱研究使得定量测量两个治疗组大脑中的金含量成为可能。金硫葡萄糖治疗以及金硫苹果酸盐治疗的动物有相当数量的黄金在大脑适当。由硫代葡萄糖金的硫部分的中子活化产生的磷32被证明是微不足道的，其贡献的放射自显影的结果。上述研究结果的影响食欲调节的葡萄糖抑制理论进行了讨论。
Administration of gold thioglucose led to the development of hyperphagia and obesity in mice; this confirmed findings by previous investigators. By employing neutron activation analysis and radioautography, it was observed that this syndrome was associated with focal accumulation of gold in the hypothalamus. Animals treated with gold thiomalate failed to show any hypothalamic localization of gold radioautographically or any evidence of the syndrome of hyperphagia and obesity. In addition, other foci of gold localization were found in gold thioglucose-treated but not in the gold thiomalate-treated animals. Gamma spectroscopy studies made possible quantitative measurements of the gold content in the brains of both treated groups. Gold thioglucose-treated as well as gold thiomalate-treated animals had appreciable quantities of gold in the brain proper. Phosphorus 32 generated by neutron activation of the sulfur moiety of gold thioglucose proved to be insignificant in its contribution to the radioautographic findings. Implication of the above findings for the glucostatic theory of appetite regulation is discussed.