Lipid carrier proteins and ethanol.
Lipid carrier proteins and ethanol.
复制标题
脂质载体蛋白和乙醇。
DOI：
10.1007/bf02255979
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发表时间：
2001
影响因子：
11
通讯作者：
Igbavboa,U
中科院分区：
文献类型：
--
作者：
Wood,WG;Avdulov,NA;Chochina,SV;Igbavboa,U
乙醇对脂类动态平衡有显著影响。我们的总体假设是，某些脂质载体蛋白是急性和慢性酒精暴露的靶标，这些蛋白的扰动导致脂质功能障碍，导致细胞病理生理。这些蛋白质包括细胞内蛋白质和脂蛋白。本文研究了乙醇与这些蛋白质相互作用的最新数据。此外，关于乙醇对成纤维细胞低密度脂蛋白(LDL)介导的胆固醇摄取的刺激作用以及直接干扰低密度脂蛋白载脂蛋白B的新数据，提出了一个细胞模型，概述了乙醇扰动胆固醇运输和分布的潜在机制。
Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid dysfunction leading to cellular pathophysiology. These proteins include both intracellular proteins and lipoproteins. This paper examines recent data on the interaction of ethanol with these proteins. In addition, new data are presented on the stimulatory effects of ethanol on low-density-lipoprotein (LDL)-mediated cholesterol uptake into fibroblasts and direct perturbation of the LDL apolipoprotein, apolipoprotein B. A cell model is presented that outlines potential mechanisms thought to be involved in ethanol perturbation of cholesterol transport and distribution.