An autonomous polymerization motor powered by DNA hybridization
An autonomous polymerization motor powered by DNA hybridization
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DOI：
10.1038/nnano.2007.225
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发表时间：
2007-08-01
影响因子：
38.3
通讯作者：
Pierce, Niles A.
中科院分区：
文献类型：
--
作者：
Venkataraman, Suvir;Dirks, Robert M.;Pierce, Niles A.
我们提出了一种能够在溶液中自主纳米级传输的合成分子马达。受立克次体等细菌病原体的启发，这种发动机通过聚合双螺旋DNA尾巴来运行，比如立克次体，它们通过诱导表面的肌动蛋白聚合形成“彗星尾巴”来移动。DNA链在生长的聚合物的活端被不断推进，展示了由DNA杂交的自由能驱动的自主运动。
We present a synthetic molecular motor capable of autonomous nanoscale transport in solution. Inspired by bacterial pathogens such as Rickettsia rickettsii, which locomote by inducing the polymerization of the protein actin at their surfaces to form 'comet tails' 1, the motor operates by polymerizing a double-helical DNA tail(2). DNA strands are propelled processively at the living end of the growing polymers, demonstrating autonomous locomotion powered by the free energy of DNA hybridization.