The effect of inhalation of essential oil from Rosmarinus officinalis on scopolamine-induced Alzheimer’s type dementia model mice
The effect of inhalation of essential oil from Rosmarinus officinalis on scopolamine-induced Alzheimer’s type dementia model mice
复制标题
迷迭香精油吸入对东莨菪碱致阿尔茨海默型痴呆模型小鼠的影响
DOI：
10.1002/ffj.3435
复制
发表时间：
2018
影响因子：
2.6
通讯作者：
Kazuo Koike
中科院分区：
文献类型：
--
作者：
Tadaaki Satou;Yuki Hanashima;Iho Mizutani;Kazuo Koike
迷迭香精油(迷迭香精油，EORO)可能通过激活中枢神经系统来改善认知功能。然而，还没有描述EORO影响的科学依据。因此，我们利用模型小鼠研究了EORO对阿尔茨海默氏型痴呆的影响。小鼠雾化吸入EORO。然后，用东莨菪碱制备阿尔茨海默型痴呆模型小鼠。为评估认知功能，采用Y迷宫测试进行短时记忆评估。EORO显著提高了自发交替行为的发生率。此外，吸入EORO后，脑组织中可检测到主要成分1，8-桉树脑、α-Pinene和β-Pinene，且呈浓度依赖关系。因此，吸入EORO可能会改善阿尔茨海默氏型痴呆模型的认知功能。1，8-桉叶素等成分可能参与了对大脑的影响。对EORO的详细作用机制的研究对于将来的临床应用是必要的。
Essential oil fromRosmarinus officinalis(Rosemary essential oil, EORO) may improve cognitive function by activating the central nervous system. However, no scientific basis for the effect of EORO has been described. Therefore, we investigated the effect of EORO on Alzheimer's type dementia using model mice. Mice were administered EORO by inhalation. Then, scopolamine was used to prepare Alzheimer's type dementia model mice. To evaluate cognitive function, the Y‐maze test was used for assessment of short‐term memory. EORO produced a significant improvement in the rate of spontaneous alternation behavior. Furthermore, 1,8‐cineole, α‐pinene, and β‐pinene, the main components of EORO, were detected in the brain in a concentration‐dependent manner following inhalation of EORO. Thus, inhalation of EORO may improve cognitive function in a model of Alzheimer's type dementia. Components such as 1,8‐cineole and others are likely involved in the effects on the brain. Examination of the detailed mechanism of action of EORO is necessary for future clinical application.