Two Repressor Elements Inhibit Expression of the von Willebrand Factor Gene Promoter In Vitro
Two Repressor Elements Inhibit Expression of the von Willebrand Factor Gene Promoter In Vitro
复制标题
两种阻遏元件在体外抑制血管性血友病因子基因启动子的表达
DOI：
10.1055/s-0037-1615234
复制
发表时间：
1998
影响因子：
6.7
通讯作者：
N. Jahroudi
中科院分区：
文献类型：
--
作者：
A. Ardekani;J. Greenberger;N. Jahroudi
Summary A fragment of the human von Willebrand factor (VWF) gene promoter corresponding to sequences –487 to +247 bp functions as an endothelial specific promoter in cell culture. We have previously reported that a GATA transcription factor functions as an activator and an NF1 like protein functions as a repressor of this promoter fragment. We have now identified a second negative regulatory element in the VWF promoter that interacts with nuclear factor(s) (designated R) in both bovine aortic endothelial and smooth muscle cells. Inhibition of either the NF1 or the R repressor alone is not sufficient to activate the VWF promoter in smooth muscle cells. The present studies reveal that simultaneous inhibition of both repressors activates the VWF promoter in smooth muscle cells. The data support a model of selective derepression to explain the endothelial cell specific activity of the –487 to +247 fragment of the VWF promoter in vitro.
DOI：
10.1073/pnas.92.10.4567
发表时间：
1995-05-09
影响因子：
11.1
作者：
AIRD, WC;JAHROUDI, N;ROSENBERG, RD
通讯作者：
ROSENBERG, RD
人类和牛血管性血友病因子编码基因 5 侧翼序列的比较揭示了高度同源结构域与物种特异性 Alu 型重复序列的交替。
影响因子：
3.5
作者：
Janel,N;Schwachtgen,JL;Bakhshi,MR;Barek,L;Meyer,D;Kerbiriou-Nabias,D
通讯作者：
Kerbiriou-Nabias,D