Spontaneous low-frequency blood oxygenation level-dependent fluctuations and functional connectivity analysis of the 'resting' brain
Spontaneous low-frequency blood oxygenation level-dependent fluctuations and functional connectivity analysis of the 'resting' brain
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DOI：
10.1016/j.mri.2008.05.008
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发表时间：
2008-09-01
影响因子：
2.5
通讯作者：
Auer, Dorothee P.
中科院分区：
文献类型：
--
作者：
Auer, Dorothee P.
与对照条件相比，使用血液氧合水平依赖性（粗体）对比度（BOLD）对比度（BOLD）对比度的功能磁共振成像技术通过将局部血液动力学反应与神经元刺激相关联。在低频范围（<0.1 Hz）中突出的自发脑大胆波动的兴趣越来越大，并且在功能网络中显示出有趣的时空相关性。这些信号波动的性质尚不清楚，但是有积累的证据依靠神经基础开放令人兴奋的新途径，以研究人脑功能及其静止的连通性。此外，越来越多的患者研究报告了低频大胆波动（LFBF）的振幅和空间相干性的疾病依赖性变化（LFBF）可能具有比标准fMRI更高的诊断敏感性和更容易的临床适用性。这种新兴工具的主要缺点与生理（呼吸道，心脏和血管症）和运动混淆有关，这些混淆是挑战性的，需要彻底的预处理。最近已经审查了功能连通性fMRI分析的技术方面以及在默认模式下自发LFBF的神经科学潜力。这篇综述将对当前有关LFBF性质的知识，它们与生理混杂关系以及临床诊断和药理研究的潜力。 （c）2008 Elsevier Inc.保留所有权利。
Functional magnetic resonance imaging techniques using the blood oxygenation level-dependent (BOLD) contrast are widely used to map human brain Function by relating local hemodynamic responses to neuronal stimuli compared to control conditions. There is increasing interest in spontaneous cerebral BOLD fluctuations that are prominent in the low-frequency range (< 0.1 Hz) and show intriguing spatio-temporal correlations in functional networks. The nature of these signal fluctuations remains unclear, but there is accumulating evidence fora neural basis opening exciting new avenues to study human brain function and its connectivity at rest. Moreover an increasing number of patient studies report disease-dependent variation in the amplitude and spatial coherence of low-frequency BOLD fluctuations (LFBF) that may afford greater diagnostic sensitivity and easier clinical applicability than standard fMRI. The main disadvantage of this emerging tool relates to physiological (respiratory, cardiac and vasomotion) and motion confounds that are challenging to disentangle requiring, thorough preprocessing. Technical aspects of functional connectivity fMRI analysis and the neuroscientific potential of spontaneous LFBF in the default mode and other restin-state networks have been recently reviewed. This review will give an update on the current knowledge of the nature of LFBF, their relation to physiological confounds and potential for clinical diagnostic and pharmacological studies. (C) 2008 Elsevier Inc. All rights reserved.