Saccadic burst neurons in the fastigial nucleus are not involved in compensating for orbital nonlinearities.
Saccadic burst neurons in the fastigial nucleus are not involved in compensating for orbital nonlinearities.
复制标题
顶核中的扫视爆发神经元不参与轨道非线性的补偿。
作者：
K. Ohtsuka;H. Sato;H. Noda
1.为了测试小脑是否参与补偿眼眶的非线性，我们记录了放电的扫视爆发神经元在小脑顶眼区（FOR）在离心和向心扫视在两个训练有素的猕猴。2.我们还研究了具有相同幅度的离心和向心扫视的度量，而来自顶核的输出信号被蝇蕈醇（muscimol）阻断，蝇蕈醇是抑制性神经递质γ-氨基丁酸（GABA）的激动剂，注入FOR。3.我们研究了32个小脑顶神经元的放电，微刺激眼蚓部抑制。这些神经元在对侧和同侧定向扫视过程中表现出独特的爆发反应，如我们以前的报告所示。放电模式、峰值爆发频率、爆发提前时间和爆发持续时间是一致的，与初始眼睛位置无关。4.蝇蕈醇注射产生的hypermetric眼跳向注射侧和hypermetric眼跳的对侧，无论眼跳是向心或离心方向。5.这些研究结果表明，FOR是不参与补偿眼跳指标的轨道非线性。
1. To test whether the cerebellum is involved in compensating for orbital nonlinearities, we recorded discharges of saccadic burst neurons in the fastigial oculomotor region (FOR) during both centrifugal and centripetal saccades in two trained macaque monkeys. 2. We also investigated the metrics of centrifugal and centripetal saccades with the same amplitude while output signals from the fastigial nucleus were blocked by muscimol, an agonist of inhibitory neurotransmitter gamma-aminobutyric acid (GABA), injected into the FOR. 3. We studied discharges of 32 fastigial neurons that were inhibited by microstimulation of the oculomotor vermis. These neurons exhibited unique burst responses during contralaterally and ipsilaterally directed saccades, as shown in our previous report. The discharge pattern, the peak burst frequency, the burst lead time, and the burst duration were consistent, regardless of initial eye position. 4. The muscimol injection produced hypermetric saccades toward the injection side and hypometric saccades to the opposite side, regardless of whether saccade was centripetally or centrifugally directed. 5. These findings suggest that the FOR is not involved in the compensation of saccade metrics for orbital nonlinearities.