Differentiation of white, mixed, and red thrombi: Value of CT in estimation of the prognosis of thrombolysis - Phantom study
Differentiation of white, mixed, and red thrombi: Value of CT in estimation of the prognosis of thrombolysis - Phantom study
复制标题
DOI：
10.1148/radiol.2273020530
复制
发表时间：
2003-07-01
期刊：
影响因子：
19.7
通讯作者：
Sartor, K
中科院分区：
文献类型：
--
作者：
Kirchhof, K;Welzel, T;Sartor, K
目的：通过连续计算机断层扫描 (CT) 扫描测试是否可以根据 CT 衰减区分白色、混合和红色血栓。 材料和方法：将富含血小板的血浆和全血混合，产生血细胞比容水平为 0、0.005、0.03、0.15 和 0.35 的样本。添加凝血酶溶液； 2小时后，将回缩的血块转移至长4cm、内径3mm的聚乙烯管中。将每个样品的十个探针放入装有明胶、钆喷酸二葡胺和蒸馏水溶液的塑料盒中。十个装有明胶的管子作为对照：用这个体模，CT数为白色，混合； 144 小时内测量了红色血栓。 CT 使用多截面扫描仪和 0.5 mm 的准直进行。对组间差异和随时间变化进行统计分析。结果：白色、混合和红色血栓的 CT 数量差异显着 (P < 0.05)。结论：通过 CT，根据血细胞比容水平区分血栓，从而评估溶栓的有效性似乎是可行的。 (C) 北美放射学会，2003 年。
PURPOSE: To test with serial computed tomographic (CT) scans whether white, mixed, and red thrombi could be differentiated according to their CT attenuation.MATERIALS AND METHODS: Platelet-enriched plasma and whole blood were mixed to produce samples with hematocrit levels of 0, 0.005, 0.03, 0.15, and 0.35. A thrombin solution was added; and after 2 hours the retracted clots were transferred into polyethylene tubes with a length of 4 cm and an inner diameter of 3 mm. Ten probes of each sample were placed into a plastic box filled with a solution of gelatin, gadopentetate dimeglumine, and distilled water. Ten tubes filled with gelatin served as control: With this phantom, the CT numbers of white, mixed; and red thrombi were measured over 144 hours. CT was performed with a multisection scanner and a collimation of 0.5, mm. Statistical analyses were performed for differences between groups and over time.RESULTS: The CT numbers of white, mixed, and red thrombi differed significantly (P .05).CONCLUSION: With CT it appears feasible to differentiate thrombi according to their hematocrit level and thus estimate the effectiveness of thrombolysis. (C) RSNA, 2003.