The epidemiology of Paget's disease in Britain: Is the prevalence decreasing?
The epidemiology of Paget's disease in Britain: Is the prevalence decreasing?
复制标题
DOI：
10.1359/jbmr.1999.14.2.192
复制
发表时间：
1999-02-01
影响因子：
6.2
通讯作者：
Barker, D
中科院分区：
文献类型：
--
作者：
Cooper, C;Schafheutle, K;Barker, D
为了估计英国佩吉特病的年龄和性别特异性患病率的变化，我们在10个英国中心对该疾病进行了放射学调查，使用的抽样和放射学方法与1974年进行的研究相同。在每个中心，从主要综合医院放射科储存的胶片中提取55岁及以上人群的腹部X线片样本，通过1993-1995年期间的筛选X线片记录识别X线片。55岁及以上受试者的任何腹部X线片，包括整个骨盆、骶骨、股骨头，所有的腰椎都进行了研究。X光片由一名受过训练的观察员和参与1974年原始调查的放射科顾问进行评估。在10个城镇中评估了9 828张X光照片（4 625名男性，5 203名女性）。总的年龄/性别标准化患病率为2%，男性/女性比率为1.6。随着年龄的增长，男性和女性的患病率急剧上升，在85岁及以上的人群中，男性患病率为6.9%，女性患病率为5.8%。1994年，10个城镇的佩吉特病患病率仅为1974年研究期间观察到的患病率的40%。患病率的下降在所有10个中心都很明显，但在最初研究中患病率高的那些中心最为明显。这项在英国10个城镇进行的佩吉特病调查表明，55岁及以上的男性患病率为2.5%，女性为1.6%，1974年至1994年，经统计学调整的患病率急剧下降，这些下降表明环境因素对这种疾病的病因学有贡献，需要进一步调查。
To estimate changes in the age- and gender-specitic prevalence of Paget's disease in Britain, we performed a radiographic survey of the disorder in 10 British centers, using sampling and radiographic methods identical to a study performed in 1974. In each center, a sample of abdominal radiographs of people aged 55 years and over was taken from stored films within the radiology department of the principal general hospital, The radiographs were identified by screening radiographic records over the period 1993-1995, Any abdominal radiograph in a subject aged 55 years and over which included the entire pel,is, sacrum, femoral heads, and all lumbar vertebrae was studied, The radiographs were evaluated by a trained observer and the consultant radiologist who participated in the original 1974 survey. Nine thousand eight hundred and twenty-eight radiographs (4625 men, 5203 women) were assessed in the 10 towns. The overall age/gender standardized prevalence rate was 2%, with a male/female ratio of 1,6. Prevalence increased steeply with age among men and women, rising to 6.9% of men and 5.8% of women aged 85 years and over. The prevalence of Paget's disease in the 10 towns in 1994 was only 40% of that observed during the 1974 study, The decline in prevalence was apparent in all 10 centers, but was most marked in those with high rates in the original study, This survey of Paget's disease in 10 British towns suggests a prevalence of 2.5% among men and 1.6% among women aged 55 years and over, Age-adjusted prevalence rates declined steeply between 1974 and 1994, These declines suggest an environmental contribution to the etiology of this disorder that requires further investigation.