Cohort Profile: Hlabisa HIV Treatment and Care Programme
Cohort Profile: Hlabisa HIV Treatment and Care Programme
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DOI：
10.1093/ije/dyp402
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发表时间：
2011-04-01
影响因子：
7.7
通讯作者：
Newell, Marie-Louise
中科院分区：
文献类型：
--
作者：
Houlihan, Catherine F.;Bland, Ruth M.;Newell, Marie-Louise
由于在资源有限的国家迅速推出并随后扩大了艾滋病毒和抗逆转录病毒服务，在2007年之前的4年里，接受抗逆转录病毒治疗的患者人数增加了7倍以上。1在低收入和中等收入国家，抗逆转录病毒疗法在个体免疫和病毒学应答方面与在高资源环境中一样有效。2、3然而，在获得治疗的障碍、4治疗的保留、5过早死亡2、6、7以及有限和耐受性较差的二线治疗方案方面仍然存在挑战。8南非有570万艾滋病毒感染者，9艾滋病毒的发病率和流行率仍然很高。10、11由于资源有限，疾病负担沉重，在农村地区推广抗逆转录病毒疗法表明，在管理这一慢性传染病方面，大多数资源匮乏的环境同样面临挑战。艾滋病毒国家计划的目标是在2007年至2012年期间将接受抗逆转录病毒疗法的人数增加两倍以上，12但如果要取得成功，就应该以适当的方案证据为指导，以便成功地控制这一流行病。本报告所述方案是卫生部和非洲卫生和人口研究中心（http：//www.非洲中心AC. za），以响应2004年艾滋病毒和艾滋病护理管理和治疗综合计划。13艾滋病毒治疗和护理由16个护士领导的初级保健诊所提供，分析将增加分散提供艾滋病毒治疗和护理的有限证据。
The rapid roll-out and subsequent scale-up of HIV and antiretroviral services in resource-limited countries has seen a> 7-fold increase in the number of patients on antiretroviral therapy (ART) over the 4 years prior to 2007. 1 ART in low-and middle-income countries has been shown to be similarly effective in terms of individual immunological and virological response as in high-resource settings. 2, 3 However, challenges remain relating to barriers to access, 4 retention on treatment, 5 early mortality2, 6, 7 and limited and less well-tolerated second-line regimens. 8In South Africa, home to 5.7 million HIV-infected persons, 9 HIV incidence and prevalence remain high. 10, 11 With a large burden of disease constrained by limited resources, the roll-out of ART in rural areas illustrates the challenge, similarly faced by most resource-poor settings, of managing this chronic infectious disease. The national plan for HIV aims to more than triple the number of individuals on ART between 2007 and 2012, 12 but if it is to be successful, should be guided by appropriate programmatic evidence to allow successful control of the epidemic. The programme reported here was implemented as a joint initiative by the Department of Health (DoH) and the Africa Centre for Health and Population Studies (http://www. africacentre. ac. za) in response to the Comprehensive HIV and AIDS Care Management and Treatment Plan in 2004. 13 HIV treatment and care are offered in 16 nurse-led primary health-care (PHC) clinics and analysis will add to the limited evidence of decentralized