Single molecule visualization of stable, stiffness-tunable, flow-conforming worm micelles
Single molecule visualization of stable, stiffness-tunable, flow-conforming worm micelles
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DOI：
10.1021/ma034120d
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发表时间：
2003-09-09
期刊：
影响因子：
5.5
通讯作者：
Discher, DE
中科院分区：
文献类型：
--
作者：
Dalhaimer, P;Bates, FS;Discher, DE
我们描述了高度稳定的蠕虫胶束超聚合物的荧光可视化。蠕虫胶束在水中自组装的非离子，嵌段共聚物两亲物。通过混合和聚合惰性和交联共聚物，我们形成了长达数十微米的胶束，其持续长度从亚微米到亚毫米连续跨越超过2个数量级。在流动中，原始蠕虫以DNA样缩放定向和伸展，并且它们的稳定性、负载能力和隐蔽性使它们成为流动密集型递送应用（例如噬菌体模拟药物载体和药物递送）的理想候选者。
We describe fluorescence visualization of highly stable worm micelle superpolymers. The worm micelles are self-assembled in water from nonionic, block copolymer amphiphiles. By blending and polymerizing inert and cross-linkable copolymers, we form micelles up to tens of microns long with persistence lengths that continuously span more than 2 orders of magnitude from submicron to submillimeter. In flow, pristine worms orient and stretch with DNA-like scaling, and their stability, loading capacity, and stealthiness make them ideal candidates for flow-intensive delivery applications such as phage-mimetic drug carriers and micropore delivery.