Structural abnormalities in nucleus accumbens in patients with panic disorder
Structural abnormalities in nucleus accumbens in patients with panic disorder
复制标题
惊恐障碍患者伏隔核结构异常
DOI：
10.1016/j.jad.2020.03.172
复制
发表时间：
2020
影响因子：
6.6
通讯作者：
Yoshio Hirayasu
中科院分区：
文献类型：
--
作者：
Haruhisa Yoshida;Takeshi Asamia;Masao Takaishi;Ryota Nakamura;Asuka Yoshimi;Thomas J. Whitford;Yoshio Hirayasu
背景：虽然惊恐障碍（PD）患者惊恐发作的发病机制已经得到了很好的研究，但PD患者经常观察到的长期恐惧记忆和回避行为的神经生物学基础尚未得到很好的研究。近年来的动物实验研究表明，延髓核（NAcc）在长时恐惧记忆和回避行为的神经生物学基础中起重要作用。评价组间NAcc相对体积和形状变形的差异。结果：PD患者双侧NAcc体积较HC明显减小（P < 0. 05），PD患者双侧NAcc体积较HC明显减小（P < 0. 05），PD患者双侧NAcc体积较HC明显减小（P < 0. 05）。在形状差异方面，与HC相比，PD患者双侧NAcc表现出显著的向内变形。PD患者右侧NAcc的形状变形程度与STAI-Trait和STAI-State测量的较高评分相关。局限性：所有患者均接受精神药物等药物治疗。此外，右侧NAcc的形状变形与特质焦虑和状态焦虑有关，而状态焦虑与回避行为有关。
Background:Although the pathogenesis of panic attacks has been well studied in patients with panic disorder (PD), the neurobiological basis of the long-term fear memories and avoidance behavior that are often observed in PD have not been well investigated. Recent animal studies have suggested that nucleus accumbens (NAcc) plays an important role in neurobiological basis of long-term fear memories and avoidance behavior.Methods:Thirty-eight patients with PD and 38 matched healthy control subjects (HC) participated in this study. Differences in relative volumes and shape deformations of NAcc were evaluated between groups. Correlation analyses were conducted to quantify the association between structuralabnormalitiesin the NAcc and trait,state anxiety measured by the State-Trait Anxiety Inventory (STAI).Results:Significant volume reductions were observed in the bilateral NAcc in the patients with PD, relative to the HC. In terms of shape differences, the PD patients demonstrated significant inward deformation of the NAcc bilaterally, compared to the HC. Degree of shape deformation in the right NAcc was associated with higher scores of the STAI-Trait,and STAI-State measuresin the PD patients.Limitations:All the patients received medication such as Psychotropic drug.Conclusion:Patients with PD showed reduced volumes in the NAcc, especially in lateral regions, compared with HC. Furthermore, shape deformation in the right NAcc was associated with trait anxietyand state anxiety, which has been associated with avoidance behavior.