Hyperoxia-induced diffuse alveolar damage in pigs:: Correlation between thin-section CT and histopathologic findings
Hyperoxia-induced diffuse alveolar damage in pigs:: Correlation between thin-section CT and histopathologic findings
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DOI：
10.1148/radiology.216.2.r00jl05531
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发表时间：
2000-08-01
期刊：
影响因子：
19.7
通讯作者：
Ando, M
中科院分区：
文献类型：
--
作者：
Ichikado, K;Suga, M;Ando, M
目得：为了确定是否在实验性高氧肺损伤的肺异常的薄层CT（CT）与弥漫性肺泡损伤（DAD）的病理阶段：材料和方法：18只幼年猪暴露于超过80%的氧气24，48，72，96，或120小时，或室内空气中密封笼。他们的切除的肺通过气管注入空气膨胀，并进行薄层CT检查。两个独立的观察者，不知道曝光时间，比较63个区域选择的CT扫描与相应的病理和组织学结果，这是独立评估由两个pathologist.Results：CT结果相关性良好，与组织学结果（p = 0.86，P < .001），这对应于病理阶段的DAD。所有正常CT衰减区域，9个不透明区域中的8个，以及15个毛玻璃样阴影区域中的2个对应于DAD的早期渗出性病理阶段。CT显示牵引性细支气管扩张的所有区域均对应于早期增殖性病理阶段。CT表现（kappa统计量> 0.60）和组织学结果（大于或等于0.70）的解释具有良好的观察者一致性。结论：尽管薄层CT不能明确描述早期渗出期，但薄层CT表现反映了DAD的病理分期。牵引性细支气管扩张的CT扫描提示进展到增殖期。
PURPOSE: To determine whether lung abnormalities at thin-section computed tomography (CT) in experimental hyperoxic lung injury correlate with the pathologic phases of diffuse alveolar damage (DAD).MATERIALS AND METHODS: Eighteen juvenile pigs were exposed to more than 80% oxygen-for 24, 48, 72, 96, or 120 hours-or room air in sealed cages. Their removed lungs were inflated with air infused through the trachea and examined with thin-section CT. Two independent observers, without knowledge of the exposure times, compared 63 areas selected on the CT scans with the corresponding pathologic and histologic findings, which were evaluated independently by two pathologists.RESULTS: CT findings correlated well with histologic findings (p = 0.86, P < .001), which corresponded to the pathologic phases of DAD. All areas of normal CT attenuation, eight of nine spared regions within areas of opacity, and two of 15 areas of ground-glass opacity corresponded to the early exudative pathologic phase of DAD. All areas that showed traction bronchiolectasis at CT corresponded to the early proliferative pathologic phase. There was good observer agreement regarding the interpretation of CT findings (kappa statistic, > 0.60) and histologic results (greater than or equal to 0.70).CONCLUSION: Thin-section CT findings reflect the pathologic phases of DAD, although the early exudative phase cannot be specifically depicted by thin-section CT. Traction bronchiolectasis on a CT scan suggests progression to the proliferative phase.