Measles virus receptors and tropism.
Measles virus receptors and tropism.
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DOI：
10.7883/yoken.jjid.2006.1
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发表时间：
2006-02
影响因子：
2.2
通讯作者：
Y. Yanagi;M. Takeda;S. Ohno;Fumio Seki
中科院分区：
文献类型：
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作者：
Y. Yanagi;M. Takeda;S. Ohno;Fumio Seki
麻疹病毒（MV）是副粘病毒科麻疹病毒属的一员。人淋巴细胞信号激活分子（SLAM）是一种MV的细胞受体。SLAM在未成熟胸腺细胞、活化淋巴细胞、巨噬细胞和成熟树突状细胞上表达。SLAM的这种分布与MV的嗜淋巴性和免疫抑制性一致。犬瘟热和牛瘟病毒，麻疹病毒属的其他成员，也使用SLAM作为受体。实验室适应的MV菌株通常通过受体结合血凝素的氨基酸变化，使用无处不在表达的CD46作为替代受体。此外，MV可以通过SLAM-和cd46 -不依赖途径感染多种培养细胞，尽管感染效率很低，这也可能是MV在体内感染SLAM（-）细胞的原因。
Measles virus (MV) is a member of the Morbillivirus genus in the Paramyxoviridae family. Human signaling lymphocyte activation molecule (SLAM) acts as a cellular receptor for MV. SLAM is expressed on immature thymocytes, activated lymphocytes, macrophages and mature dendritic cells. This distribution of SLAM is in accord with lymphotropism and immunosuppressive nature of MV. Canine distemper and rinderpest viruses, other members of the Morbillivirus genus, also use SLAM as receptors. Laboratory-adapted MV strains often use ubiquitously expressed CD46 as an alternative receptor through the amino acid change(s) in the receptor-binding hemagglutinin. Furthermore, MV can infect various cultured cells, albeit with very low efficiency, via SLAM- and CD46-independent pathway, which may also account for MV infection of SLAM(-) cells in vivo.